10331-57-4

Basic information

• Product Name: NICLOFOLAN
• Synonyms: NICLOFOLAN;Niclofoian;1'-biphenyl)-2,2'-diol, 5,5'-dichloro-3,3'-dinitro-(;3,3'-dichloro-5,5'-dinitro-o,o'-biphenol;4,4'-dichloro-6,6'-dinitro-o,o'-biphenol;5,5'-dichloro-2,2'-dihydroxy-3,3'-dinitrobiphenyl;5,5'-dichloro-3,3'-dinitro(1,1'-biphenyl)-2,2'-diol;menichlopholan
• CAS NO: 10331-57-4
• Molecular Formula: C₁₂H₆Cl₂N₂O₆
• Molecular Weight: 345.09
• EINECS: 233-720-0
• Product Categories: API
• Mol File: 10331-57-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 251.5°C (rough estimate)
• Flash Point: 210.8°C
• Appearance: /
• Density: 1.8594 (rough estimate)
• Vapor Pressure: 8.03E-08mmHg at 25°C
• Refractive Index: 1.7350 (estimate)
• PKA: 4.34±0.40(Predicted)
• CAS DataBase Reference: NICLOFOLAN(CAS DataBase Reference)
• NIST Chemistry Reference: NICLOFOLAN(10331-57-4)
• EPA Substance Registry System: NICLOFOLAN(10331-57-4)

Safety Data

• Hazardous Substances Data: 10331-57-4(Hazardous Substances Data)

Usage

General Description

Niclofolan, also known as dioxantin, is a potent anthelmintic agent used to treat parasitic infections in domestic animals. It belongs to the group of benzimidazole derivatives and works by disrupting the energy metabolism of the parasites, leading to their immobilization and eventual death. Niclofolan is effective against a wide range of intestinal and tissue-dwelling parasites, including roundworms, tapeworms, and flukes. It is commonly administered orally or via injection and is known for its high safety margin and low toxicity in animals. However, due to its potential environmental and human health hazards, the use of niclofolan is subject to strict regulations in many countries.

InChI:InChI=1/C12H6Cl2N2O6/c13-5-1-7(11(17)9(3-5)15(19)20)8-2-6(14)4-10(12(8)18)16(21)22/h1-4,17-18H

Upstream product

• 31113-52-7 2,2'-Dihydroxy-5,5'-dichlorobiphenyl 

Downstream Products

• 25706-45-0 3,3'-diaminobiphenyl-2,2'-diol 

Relevant articles and documents

3-(Ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium cation: A green alternative to tert-butyl nitrite for synthesis of nitro-group-containing arenes and drugs at room temperature

Due to their remarkable properties, task-specific ionic liquids have turned out to be progressively popular over the last few years in the field of green organic synthesis. Herein, for the first time, we report that a new task-specific nitrite-based ionic liquid such as 3-(ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium bis(trifluoromethanesulfonyl)imides (TS-N-IL) derived from biodegradable ethyl nicotinate indeed acted as an efficient and eco-friendly reagent for the synthesis of highly valuable nitroaromatic compounds and drugs including nitroxynil, tolcapone, niclofolan, flutamide, niclosamide and nitrazepam. The bridging of an ionic liquid with nitrite group not only increases the yield and rate of direct C[sbnd]N bond formation reaction but also allows easy product separation and recyclability of a byproduct. Nonvolatile nature, easy synthesis, merely stoichiometric need and mildness are a portion of the extra focal points of TS-N-IL while contrasted with tert-butyl nitrite an outstanding and highly-flammable reagent utilized largely in organic synthesis.