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103387-07-1

103387-07-1

Identification

Synonyms:2-nitro-3,4,5-trimethoxybenzyl bromide;2-Nitro-3,4,5-trimethoxy-benzylbromid;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:Labseeker
  • Product Description:1-(bromomethyl)-3,4,5-trimethoxy-2-nitrobenzene 95
  • Packaging:10g
  • Price:$ 1699
  • Delivery:In stock
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Relevant articles and documentsAll total 2 Articles be found

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

Chang, Jang-Yang,Yang, Ming-Fang,Chang, Chi-Yen,Chen, Chi-Ming,Kuo, Ching-Chuan,Liou, Jing-Ping

, p. 6412 - 6415 (2006)

A novel series of 2-amino and 2′-aminocombretastatin derivatives were synthesized and evaluated for antitumor activity. Several compounds had excellent antiproliferative activity as inhibitors of tubulin polymerization. Compounds 11, 20, and 21 with ICsu

Process route upstream and downstream products

Process route

(3,4,5-trimethoxy-2-nitrophenyl)methanol
5435-28-9

(3,4,5-trimethoxy-2-nitrophenyl)methanol

2-nitro-3,4,5-trimethoxybenzyl bromide
103387-07-1

2-nitro-3,4,5-trimethoxybenzyl bromide

Conditions
Conditions Yield
With phosphorus tribromide; In dichloromethane; for 2h; cooling;
68%
Multi-step reaction with 2 steps
1: NaH
2: LiBr
With sodium hydride; lithium bromide;
With phosphorus tribromide; In dichloromethane; at 0 ℃; for 2h;
3,4,5-trimethoxy-2-nitrobenzoic acid
66907-52-6

3,4,5-trimethoxy-2-nitrobenzoic acid

2-nitro-3,4,5-trimethoxybenzyl bromide
103387-07-1

2-nitro-3,4,5-trimethoxybenzyl bromide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: BH3 / tetrahydrofuran / 2 h / Heating
2: 68 percent / PBr3 / CH2Cl2 / 2 h / cooling
With borane; phosphorus tribromide; In tetrahydrofuran; dichloromethane;
Multi-step reaction with 3 steps
1: NaBH4, BF3-Et2O
2: NaH
3: LiBr
With sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium hydride; lithium bromide;
Multi-step reaction with 2 steps
1: borane-THF / 3 h / Heating / reflux
2: phosphorus tribromide / dichloromethane / 2 h / 0 °C
With borane-THF; phosphorus tribromide; In dichloromethane;
2-Nitro-3,4,5-trimethoxy-benzyl-p-toluolsulfonsaeureester
101585-71-1

2-Nitro-3,4,5-trimethoxy-benzyl-p-toluolsulfonsaeureester

2-nitro-3,4,5-trimethoxybenzyl bromide
103387-07-1

2-nitro-3,4,5-trimethoxybenzyl bromide

Conditions
Conditions Yield
With lithium bromide;
3,4,5-trimethoxybenzoic acid methyl ester
1916-07-0

3,4,5-trimethoxybenzoic acid methyl ester

2-nitro-3,4,5-trimethoxybenzyl bromide
103387-07-1

2-nitro-3,4,5-trimethoxybenzyl bromide

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: Cu(NO3)2, Ac2O
2: (alkaline hydrolysis)
3: NaBH4, BF3-Et2O
4: NaH
5: LiBr
With sodium tetrahydroborate; boron trifluoride diethyl etherate; acetic anhydride; sodium hydride; copper(II) nitrate; lithium bromide;
3,4,5-trimethoxy-2-nitrobenzoic acid methyl ester
5081-42-5

3,4,5-trimethoxy-2-nitrobenzoic acid methyl ester

2-nitro-3,4,5-trimethoxybenzyl bromide
103387-07-1

2-nitro-3,4,5-trimethoxybenzyl bromide

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: (alkaline hydrolysis)
2: NaBH4, BF3-Et2O
3: NaH
4: LiBr
With sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium hydride; lithium bromide;
2-nitro-3,4,5-trimethoxybenzyl bromide
103387-07-1

2-nitro-3,4,5-trimethoxybenzyl bromide

triphenylphosphine
603-35-0

triphenylphosphine

2-nitro-3,4,5-(trimethoxybenzyl)triphenylphosphonium bromide

2-nitro-3,4,5-(trimethoxybenzyl)triphenylphosphonium bromide

Conditions
Conditions Yield
In toluene; for 3h; Heating;
74%
In toluene; for 3 - 5h; Heating / reflux;
74%
2-nitro-3,4,5-trimethoxybenzyl bromide
103387-07-1

2-nitro-3,4,5-trimethoxybenzyl bromide

C<sub>32</sub>H<sub>25</sub>NO<sub>12</sub>

C32H25NO12

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: silver oxide / benzene / Heating
2: 99 percent / CrO3, H2SO4
With chromium(VI) oxide; sulfuric acid; silver(l) oxide; In benzene;
Multi-step reaction with 2 steps
1: silver oxide / benzene / Heating
2: 99 percent / CrO3, H2SO4
With chromium(VI) oxide; sulfuric acid; silver(l) oxide; In benzene;
Multi-step reaction with 2 steps
1: silver oxide / benzene / Heating
2: 99 percent / CrO3, H2SO4
With chromium(VI) oxide; sulfuric acid; silver(l) oxide; In benzene;
2-nitro-3,4,5-trimethoxybenzyl bromide
103387-07-1

2-nitro-3,4,5-trimethoxybenzyl bromide

C<sub>36</sub>H<sub>33</sub>NO<sub>12</sub>
111742-65-5

C36H33NO12

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: silver oxide / benzene / Heating
2: 99 percent / CrO3, H2SO4
With chromium(VI) oxide; sulfuric acid; silver(l) oxide; In benzene;
Multi-step reaction with 2 steps
1: silver oxide / benzene / Heating
2: 99 percent / CrO3, H2SO4
With chromium(VI) oxide; sulfuric acid; silver(l) oxide; In benzene;
Multi-step reaction with 2 steps
1: silver oxide / benzene / Heating
2: 99 percent / CrO3, H2SO4
With chromium(VI) oxide; sulfuric acid; silver(l) oxide; In benzene;
2-nitro-3,4,5-trimethoxybenzyl bromide
103387-07-1

2-nitro-3,4,5-trimethoxybenzyl bromide

C<sub>24</sub>H<sub>18</sub>O<sub>7</sub>

C24H18O7

C<sub>34</sub>H<sub>29</sub>NO<sub>12</sub>

C34H29NO12

Conditions
Conditions Yield
With silver(l) oxide; In benzene; Yield given; Heating;
2-nitro-3,4,5-trimethoxybenzyl bromide
103387-07-1

2-nitro-3,4,5-trimethoxybenzyl bromide

C<sub>27</sub>H<sub>24</sub>O<sub>7</sub>

C27H24O7

C<sub>37</sub>H<sub>35</sub>NO<sub>12</sub>

C37H35NO12

Conditions
Conditions Yield
With silver(l) oxide; In benzene; Yield given; Heating;

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