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103392-94-5

103392-94-5

Identification

Synonyms:1-Methoxy-8-phenylnaphthalene

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 3 Articles be found

Stabilization of excited state using through-space interaction between independent π-systems mediated by a peri-substituted hydroxy group in 1-arylnaphthalenes: Unexpected blue emission of 1,3,5-tris(peri-hydroxynaphthyl) benzene

Nakajima, Hideto,Yasuda, Makoto,Shimizu, Kenji,Toyoshima, Naomi,Tsukahara, Yasunori,Kobayashi, Takao,Nakamura, Shinichiro,Chiba, Kouji,Baba, Akio

, p. 1118 - 1129 (2011)

The control of photoluminescence wavelength is important for the design of emitting materials, and compounds bearing arylaryl bonds are considered to be useful candidates for the synthesis of these materials. However, the biaryl system lacks an efficient

Chiral 2-(2-hydroxyaryl)alcohols (HAROLs) with a 1,4-diol scaffold as a new family of ligands and organocatalysts

Dilek, ?mer,Tezeren, Mustafa A.,Tilki, Tahir,Ertürk, Erkan

, p. 268 - 286 (2017/12/06)

Efficient and modular syntheses of chiral 2-(2-hydroxyaryl)alcohols (HAROLs), novel 1,4-diols carrying one phenolic and one alcohol hydroxyl group, have been developed which led to generation of a small library of structurally diverse HAROLs in enantiomerically pure form. Of the different HAROLs examined, a HAROL based on the indan backbone exhibited the highest activity and enantioselectivity in the 1,2-addition of certain organometallic compounds to aldehydes in the presence of Ti(OiPr)4 (up to 97% y, 88% ee) and performed as a hydrogen-bond donor organocatalyst in the Morita-Baylis-Hillman reaction, promoted by trialkylphosphines.

Process route upstream and downstream products

Process route

8-phenylnaphthalen-1-ol
129957-20-6

8-phenylnaphthalen-1-ol

dimethyl sulfate
77-78-1

dimethyl sulfate

1-methoxy-8-phenylnaphthalene
103392-94-5

1-methoxy-8-phenylnaphthalene

Conditions
Conditions Yield
8-phenylnaphthalen-1-ol; With potassium carbonate; for 0.25h; Inert atmosphere;
dimethyl sulfate; In acetone; at 20 - 75 ℃; for 16h; Inert atmosphere;
90%
bromobenzene
108-86-1,52753-63-6

bromobenzene

8-methoxy-naphthalen-1-ylboronic acid

8-methoxy-naphthalen-1-ylboronic acid

1-methoxy-8-phenylnaphthalene
103392-94-5

1-methoxy-8-phenylnaphthalene

Conditions
Conditions Yield
8-methoxy-naphthalen-1-ylboronic acid; With sodium carbonate; In ethanol; water; toluene; at 20 ℃; for 1h;
bromobenzene; With tetrakis(triphenylphosphine) palladium(0); In ethanol; water; toluene; at 90 ℃; for 3h;
78%
5-exo-(3-methoxyphenyl)-6-exo-(2-phenylethynyl)bicyclo[2.2.1]hept-2-ene

5-exo-(3-methoxyphenyl)-6-exo-(2-phenylethynyl)bicyclo[2.2.1]hept-2-ene

1-methoxy-8-phenylnaphthalene
103392-94-5

1-methoxy-8-phenylnaphthalene

methyl-(5-phenyl-[2]naphthyl)-ether
27331-47-1

methyl-(5-phenyl-[2]naphthyl)-ether

Conditions
Conditions Yield
With palladium diacetate; 2-(pyrazol-1-yl)pyridine; In acetic acid; dimethyl sulfoxide; at 80 ℃; for 16h;
58%
5%
1-Methoxynaphthalene
2216-69-5

1-Methoxynaphthalene

1-methoxy-8-phenylnaphthalene
103392-94-5

1-methoxy-8-phenylnaphthalene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: tert.-butyl lithium
2.1: sodium carbonate / ethanol; water; toluene / 1 h / 20 °C
2.2: 3 h / 90 °C
With tert.-butyl lithium; sodium carbonate; In ethanol; water; toluene; 2.2: Suzuki coupling;
iodobenzene
591-50-4

iodobenzene

1-methoxy-8-phenylnaphthalene
103392-94-5

1-methoxy-8-phenylnaphthalene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: palladium diacetate; caesium carbonate / N,N-dimethyl-formamide / 20 °C / Molecular sieve; Inert atmosphere
1.2: 16 h / 125 °C / Inert atmosphere
2.1: potassium carbonate / 0.25 h / Inert atmosphere
2.2: 16 h / 20 - 75 °C / Inert atmosphere
With palladium diacetate; potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide;
1-methoxy-8-phenylnaphthalene
103392-94-5

1-methoxy-8-phenylnaphthalene

Conditions
Conditions Yield
With chloranil; methoxybenzene;
styrene oxide
96-09-3

styrene oxide

1-methoxy-8-phenylnaphthalene
103392-94-5

1-methoxy-8-phenylnaphthalene

C<sub>25</sub>H<sub>22</sub>O<sub>2</sub>

C25H22O2

Conditions
Conditions Yield
1-methoxy-8-phenylnaphthalene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 3h; Schlenk technique; Inert atmosphere;
styrene oxide; With boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Schlenk technique; Inert atmosphere;
1-methoxy-8-phenylnaphthalene
103392-94-5

1-methoxy-8-phenylnaphthalene

(S)-(-)-2-(1-hydroxy-8-phenylnaphthalen-2-yl)-1-phenylethanol

(S)-(-)-2-(1-hydroxy-8-phenylnaphthalen-2-yl)-1-phenylethanol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran; hexane / 3 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
1.2: 1 h / -78 °C / Schlenk technique; Inert atmosphere
2.1: sodium t-butanolate; ethanethiol / N,N-dimethyl-formamide / 0 - 120 °C / Schlenk technique; Inert atmosphere
With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; ethanethiol; sodium t-butanolate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

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