10346-50-6Relevant articles and documents
Facile syntheses of 3-halo and mixed 3,5-dihalo analogues of N-acetyl-l-tyrosine via sulfonic acid-catalysed regioselective monohalogenation
Bovonsombat, Pakorn,Khanthapura, Pratheep,Krause, Michael M.,Leykajarakul, Juthamard
scheme or table, p. 7008 - 7011 (2009/04/10)
The combination of catalytic amounts of p-toluenesulfonic acid and 1 equiv of N-halosuccinimide afforded highly selective ring-halogenation of N-acetyl-l-tyrosine, furnishing either N-acetyl-3-halo-l-tyrosine analogues or mixed 3,5-dihalo derivatives in a one-pot reaction with excellent yields at room temperature.