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Cas Database

1035113-22-4

1035113-22-4

Identification

  • Product Name:C33H40O11

  • CAS Number: 1035113-22-4

  • EINECS:

  • Molecular Weight:612.674

  • Molecular Formula: C33H40O11

  • HS Code:

  • Mol File:1035113-22-4.mol

Synonyms:C33H40O11

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Relevant articles and documentsAll total 2 Articles be found

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation

Zhao, Yu,Su, Jia,Goto, Masuo,Morris-Natschke, Susan L.,Li, Yan,Zhao, Qin-Shi,Yao, Zhu-Jun,Lee, Kuo-Hsiung

, p. 4749 - 4757 (2013/07/19)

Taxchinin A, with a 11(15→1)-abeo-taxane skeleton, is a major, but inactive taxoid contained in leaves of Taxus chinensis. In our design of dual-functional antitumor abeo-taxane derivatives, two fragments from antitumor agents with different molecular tar

Synthesis, cytotoxic activity, and SAR analysis of the derivatives of taxchinin A and brevifoliol

Zhao, Yu,Guo, Na,Lou, Li-Guang,Cong, Yu-Wen,Peng, Li-Yan,Zhao, Qin-Shi

, p. 4860 - 4871 (2008/12/22)

Twenty-one derivatives of taxchinin A (1) and brevifoliol (2) were synthesized and evaluated for cytotoxicity against human non-small lung cancer (A549) cell line. Nine derivatives showed potent activity with IC50 values from 0.48 to 6.22 μM. 5

Process route upstream and downstream products

Process route

C<sub>39</sub>H<sub>54</sub>O<sub>11</sub>Si
1035113-20-2

C39H54O11Si

C<sub>33</sub>H<sub>40</sub>O<sub>11</sub>
1035113-22-4

C33H40O11

Conditions
Conditions Yield
With pyridine; hydrogen fluoride; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;
87%
C<sub>39</sub>H<sub>54</sub>O<sub>11</sub>Si
1035113-20-2

C39H54O11Si

C<sub>31</sub>H<sub>36</sub>O<sub>9</sub>
1035113-21-3

C31H36O9

C<sub>33</sub>H<sub>40</sub>O<sub>11</sub>
1035113-22-4

C33H40O11

Conditions
Conditions Yield
With pyridine; hydrogen fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
45.6%
32%
C<sub>39</sub>H<sub>56</sub>O<sub>11</sub>Si
1035113-18-8

C39H56O11Si

C<sub>33</sub>H<sub>40</sub>O<sub>11</sub>
1035113-22-4

C33H40O11

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: pyridinium chlorochromate / dichloromethane / 8 h / 20 °C / Inert atmosphere
2: hydrogen fluoride; pyridine / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
With pyridine; hydrogen fluoride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water;
acetoxybrevifoliol
146621-74-1

acetoxybrevifoliol

C<sub>33</sub>H<sub>40</sub>O<sub>11</sub>
1035113-22-4

C33H40O11

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 10 h / -40 °C / Inert atmosphere
2: pyridinium chlorochromate / dichloromethane / 8 h / 20 °C / Inert atmosphere
3: hydrogen fluoride; pyridine / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
With pyridine; 1H-imidazole; hydrogen fluoride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
C<sub>39</sub>H<sub>54</sub>O<sub>11</sub>Si
1035113-20-2

C39H54O11Si

C<sub>33</sub>H<sub>40</sub>O<sub>11</sub>
1035113-22-4

C33H40O11

Conditions
Conditions Yield
With pyridine; hydrogen fluoride; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;
87%
C<sub>39</sub>H<sub>54</sub>O<sub>11</sub>Si
1035113-20-2

C39H54O11Si

C<sub>31</sub>H<sub>36</sub>O<sub>9</sub>
1035113-21-3

C31H36O9

C<sub>33</sub>H<sub>40</sub>O<sub>11</sub>
1035113-22-4

C33H40O11

Conditions
Conditions Yield
With pyridine; hydrogen fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
45.6%
32%
C<sub>39</sub>H<sub>56</sub>O<sub>11</sub>Si
1035113-18-8

C39H56O11Si

C<sub>33</sub>H<sub>40</sub>O<sub>11</sub>
1035113-22-4

C33H40O11

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: pyridinium chlorochromate / dichloromethane / 8 h / 20 °C / Inert atmosphere
2: hydrogen fluoride; pyridine / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
With pyridine; hydrogen fluoride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water;
acetoxybrevifoliol
146621-74-1

acetoxybrevifoliol

C<sub>33</sub>H<sub>40</sub>O<sub>11</sub>
1035113-22-4

C33H40O11

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 10 h / -40 °C / Inert atmosphere
2: pyridinium chlorochromate / dichloromethane / 8 h / 20 °C / Inert atmosphere
3: hydrogen fluoride; pyridine / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
With pyridine; 1H-imidazole; hydrogen fluoride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

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