103748-25-0

Basic information

• Product Name: 1H-Benzimidazol-2-amine,5-chloro-1-methyl-(9CI)
• Synonyms: 1H-Benzimidazol-2-amine,5-chloro-1-methyl-(9CI);5-CHLORO-1-METHYL-2-AMINOBENZIMIDAZOLE;5-chloro-1-Methyl-1H-benzo[d]iMidazol-2-aMine
• CAS NO: 103748-25-0
• Molecular Formula: C₈H₈ClN₃
• Molecular Weight: 181.62
• Product Categories: BENZIMIDAZOLE
• Mol File: 103748-25-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 370.1°Cat760mmHg
• Flash Point: 177.6°C
• Appearance: /
• Density: 1.45g/cm³
• Vapor Pressure: 1.13E-05mmHg at 25°C
• Refractive Index: 1.687
• CAS DataBase Reference: 1H-Benzimidazol-2-amine,5-chloro-1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-2-amine,5-chloro-1-methyl-(9CI)(103748-25-0)
• EPA Substance Registry System: 1H-Benzimidazol-2-amine,5-chloro-1-methyl-(9CI)(103748-25-0)

Safety Data

• Hazardous Substances Data: 103748-25-0(Hazardous Substances Data)

Usage

Structure

A derivative of benzimidazole with a chloro group and a methyl group attached to the benzimidazole ring

Classification

Heterocyclic aromatic organic compound

Functional groups

Amine, chloro, and methyl groups

Applications

Building block in the synthesis of pharmaceuticals and other organic compounds

Biological and pharmacological properties

May have various properties due to its unique structure

Interest

Research and development in the pharmaceutical and chemical industries

Registry number

9CI (Chemical Abstracts Service Registry Number)

Solubility

Not specified in the material provided

Stability

Not specified in the material provided

Reactivity

Not specified in the material provided

Toxicity

Not specified in the material provided

Environmental impact

Not specified in the material provided

Safety precautions

Not specified in the material provided

Storage

Not specified in the material provided

InChI:InChI=1/C8H8ClN3/c1-12-7-3-2-5(9)4-6(7)11-8(12)10/h2-4H,1H3,(H2,10,11)

Upstream product

• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 59681-66-2 4-chloro-1-N-methylbenzene-1,2-diamine 
• 103748-12-5 2-(4chloro-N-methyl-2-nitranilino)ethanol 
• 103748-20-5 (Z)-3-Chloro-10-methyl-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-ylamine; hydrochloride 
• 15950-17-1 4-chloro-N-methyl-2-nitroaniline 
• 89-61-2 2,5-dichloronitrobenzene 
• 103748-15-8 (4-Chloro-2-nitro-phenyl)-methyl-(2-thiocyanato-ethyl)-amine 
• 103748-08-9 Methanesulfonic acid 2-[(4-chloro-2-nitro-phenyl)-methyl-amino]-ethyl ester 

Downstream Products

• 120625-25-4 N-(5-Chloro-1-methyl-1H-benzoimidazol-2-yl)-4-methyl-benzamide 
• 120625-24-3 N-(5-Chloro-1-methyl-1H-benzoimidazol-2-yl)-benzamide 
• 120625-26-5 N-(5-Chloro-1-methyl-1H-benzoimidazol-2-yl)-4-methoxy-benzamide 

Relevant articles and documents

A facile synthesis of 2-aminobenzoxazoles and 2-aminobenzimidazoles using N -cyano- N -phenyl- P -toluenesulfonamide (NCTS) as an efficient electrophilic cyanating agent

A facile synthesis of 2-aminobenzoxazole and 2-aminobenzimidazole derivatives employing a nonhazardous electrophilic cyanating agent: N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) with various substituted 2-aminophenols and benzene-1,2-diamine derivatives in the presence of lithium hexamethyldisilazide (LiHMDS) is described. This novel protocol boasts operational simplicity, shorter reaction time, and simple workup.

BENZOXADIAZOCINES, BENZOTHIADIAZOCINES AND BENZOTRIAZOCINES-V; THE SYNTHESIS OF SOME 2-AMINO-6-METHYL- AND 2-AMINO-6-PHENYL-5,6-DIHYDRO-4H-3,1,6-BENZOTHIADIAZOCINES

A method is described for the synthesis of hydrochlorides of some type 8 title compounds in which the nucleophilicity of N-2 is reduced or completely lost so as to prevent ring contraction reactions and, as a result, making these compounds comparatively s