1044183-50-7

Basic information

• Product Name: 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1044183-50-7
• Molecular Weight: 288.39
• Mol File: 1044183-50-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester(1044183-50-7)
• EPA Substance Registry System: 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester(1044183-50-7)

Safety Data

• Hazardous Substances Data: 1044183-50-7(Hazardous Substances Data)

Upstream product

• 13035-19-3 4-aminopiperidine 
• 100-52-7 benzaldehyde 
• 1029643-92-2 N-phenylmethylidenepiperidinyl-4-amine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1401532-90-8 3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide 
• 359877-98-8 tert-butyl 4-((3-bromophenyl)methyl)aminopiperidine carboxylate 
• 1401533-28-5 C₁₉H₂₉N₃O₃ 
• 888944-30-7 tert-butyl 4-((4-cyanobenzyl)amino)piperidine-1-carboxylate 
• 883516-51-6 4-[(furan-2-ylmethyl)amino]piperidin-1-carboxylic acid tert-butyl ester 
• 1401533-09-2 C₃₁H₃₁Cl₂N₃O₃S 
• 1401533-10-5 C₃₁H₃₁ClFN₃O₃S 
• 1401533-12-7 C₂₆H₂₈BrClN₂O₃S 
• 1401533-13-8 C₂₈H₃₂ClN₃O₄S 
• 1401533-14-9 C₂₈H₃₁Cl₂N₃O₄S 
• 1401533-15-0 C₂₈H₃₁ClFN₃O₄S 
• 1401533-17-2 C₂₇H₂₈ClN₃O₃S 
• 1401533-18-3 C₂₇H₂₇Cl₂N₃O₃S 
• 1401533-19-4 C₂₇H₂₇ClFN₃O₃S 

Relevant articles and documents

Palladium-mediated N-arylation of heterocyclic diamines: Insights into the origin of an unusual chemoselectivity

The chemoselectivity of the palladium-mediated reaction of bromobenzene with various heterocyclic diamines was studied. Whatever the ligand used, 3-aminopyrrolidine underwent arylation of the secondary amine function (> 82%), whereas the more flexible 3-aminoazepinine was arylated on its primary function (>70%). The ratio "arylation of primary amine versus arylation of secondary amine" of 3-aminopiperidine with bromobenzene varied from 90:10 (BINAP, electron-enriched and hindered biphenyls L2 or L3) to 32:68 with the Josiphos-type ligand L10. The same trend was observed when 4-aminopiperidine was used (82:18 with L2 and 17:83 with L10). This selectivity can be tuned by the choice of aryl halide partners having different steric and electronic properties. A cooperative effect of both nitrogens of diamines during the reaction was deduced from competitive experiments. Finally, 13C and 31P NMR experiments, carried out with 3-aminopyrrolidine at room temperature, support a fast coordination of the primary amine to the metal. Indeed, a palladium complex resulting from the unusual displacement of one phosphane group of the intermediate ArPdX(BINAP) by the primary amino group was characterized.

SOLUBLE EPOXIDE HYDROLASE INHIBITORS

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