104872-04-0Relevant articles and documents
A stereoselective synthesis of (-)-tetrahydrolipstatin
Ghosh, Arun K.,Liu, Chunfeng
, p. 1743 - 1744 (1999)
A stereoselective synthesis of (-)-tetrahydrolipstatin has been accomplished utilizing olefin metathesis of an acrylate ester as the key step.
COMPOUNDS FOR THE REDUCING LIPOTOXIC DAMAGE
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Page/Page column 4, (2019/01/30)
Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: (I) (II) or a pharmaceutically acceptable salt thereof.
Weight-reducing medicine orlistat synthesis method
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Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0036, (2017/08/28)
The invention discloses a weight-reducing medicine orlistat synthesis method. The synthesis method includes that in existence of (R,R)-(-)-N,N'-bis(3,5-ditert-butyl-salicylidene)-1,2-cyclohexyl diamine cobalt, lipstatin and sodium borohydride are subjected to reduction reaction under catalysis of cuprous chloride to obtain orlistat. The orlistat synthesis method is quick in reaction, and reaction yield is increased effectively. By adoption of (R,R)-(-)-N,N'-bis(3,5-ditert-butyl-salicylidene)-1,2-cyclohexyl diamine cobalt as a stabilizer of a reducing agent, low side reaction quantity, easiness in product purification and suitableness for industrial expanded production are realized.
