105149-00-6

Usage

Uses

Used in Veterinary Medicine:
Osaterone acetate is used as a therapeutic agent for the treatment of benign prostatic hyperplasia in dogs, as it effectively inhibits the production and action of male sex hormones, leading to a reduction in prostate size and alleviation of symptoms.
Used in Experimental Human Medicine:
Osaterone acetate is being investigated for potential use as a treatment for hormone-sensitive prostate cancer in humans. However, its application in this field is still experimental, and further research is required to establish its safety and efficacy.

InChI:InChI=1/C22H27ClO5/c1-12(24)22(28-13(2)25)8-6-16-14-9-18(23)17-10-19(26)27-11-20(17,3)15(14)5-7-21(16,22)4/h9-10,14-16H,5-8,11H2,1-4H3/t14-,15+,16+,20-,21+,22+/m1/s1

Upstream product

• 105149-02-8 17α-acetoxy-6β-chloro-7α-mesyloxy-2-oxa-4-pregnene-3,20-dione 
• 105149-01-7 6β-chloro-7α-hydroxy-3,20-dioxo-2-oxapregna-4-en-17-yl acetate 
• 98-59-9 p-toluenesulfonyl chloride 
• 105162-13-8 17-acetoxy-6α,7α-epoxy-2-oxapregn-4-ene-3,20-dione 
• 142967-40-6 7α,17-diacetoxy-6β-chloro-2-oxapregn-4-ene-3,20-dione 
• 139012-88-7 17-acetoxy-6-chloro-1α-hydroxy-2-oxapregna-4,6-diene-3,20-dione 
• 143058-80-4 17-acetoxy-6α,7α-epoxy-1α-hydroxy-2-oxapregn-4-ene-3,20-dione 
• 2668-75-9 3,20-dioxopregna-1,4,6-trien-17α-yl acetate 
• 15143-02-9 17-acetoxy-6α,7α-epoxypregna-1,4-diene-3,20-dione 

Downstream Products

• 105149-04-0 2-oxachlormadinone 

Relevant academic research and scientific papers

Antiandrogen. I. 2-Azapregnane and 2-oxapregnone steroids

2-Azachlormadinone acetate (5a, 17-acetoxy-6-chloro-2-azapregna-4,6-diene-3,20-dione), 2-oxachlormadinone acetate (6, 17-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione) and the derivatives were prepared as potential antiandrogenic agents. Biological evaluation showed that 5a and 6 had a potent antiandrogenic activity when tested in the castrated male rat.

2-oxa- or -aza-pregnane compounds

A compound represented by the following formula STR1 wherein A represents a hydrogen atom or a lower alkanoyl group, Z represents an oxygen atom or the group STR2 in which R represents a hydrogen atom or a lower alkyl group, and X represents a halogen atom, the compound being useful for controlling androgen-dependent diseases, particularly for preventing prostatic hypertrophy.