105326-65-6Relevant articles and documents
DRUG DISCHARGE PUMP INHIBITORS
-
, (2008/06/13)
A medicament for preventive and/or therapeutic treatment of a microbial infection having an activity of eliminating resistance of a microorganism with acquired resistance to an antimicrobial agent, which comprises as an active ingredient a compound represented by the following general formula (I), a physiologically acceptable salt thereof, or a hydrate thereof: wherein R1 and R2 independently represent hydrogen atom, a halogen atom, carboxyl group and the like; J1 represents a 5- or 6-membered heteroaromatic ring; W1 represents -CH=CH-, -C≡C-, -CH2CH2- and the like; A1 represents phenylene group, pyridinediyl group, furandiyl group and the like; G1 represents oxygen atom, carbonyl group, ethynyl group and the like; p represents an integer of from 0 to 3; G2 represents phenylene group, furandiyl group, tetrahydrofurandiyl group and the like; G3 represents -CH2- or single bond; m and n represent an integer of 0 or 1; and Q1 represents an acidic group.
Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist
Tvaermose-Nielsen, Ole,Rachlin, Schneur,Dannacher, Heinz,Bjoerkling, Fredrik,Kirstein, Dorte,Bramm, Erik,Kaergaard Nielsen, Christian,Mortensen, Jens Thing,Binderup, Lise
, p. 415 - 427 (2007/10/03)
The present paper describes the structural modifications leading to the discovery of a new series of quinoline-containing cys-LT1 receptor (LTD4 receptor) antagonists. A structural optimization with respect to the in vitro receptor b
LEUKOTRIENE-INHIBITING SUBSTITUTED (QUINOLIN-2-YL-METHOXY)PHENYL-N,N'-SULPHONYLUREAS AND USE THEREAS
-
, (2008/06/13)
Lipoxygenase-inhibiting and leukotriene-inhibiting substituted (quinolin-2-yl-methoxy)phenyl-N,N'-sulphonylureas of the formula and physiologically acceptable salts thereof