Welcome to LookChem.com Sign In|Join Free

Cas Database

1053655-66-5

1053655-66-5

Identification

Synonyms:7-Bromo[1,2,4]triazolo[1,5-a]pyridine;7-Bromo[1,2,4]triazolo[1,...;7-broMo-[1

Post Buying Request Now

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:7-Bromo[1,2,4]triazolo[1,5-a]pyridine
  • Packaging:1g
  • Price:$ 175
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:7-Bromo[1,2,4]triazolo[1,5-a]pyridine
  • Packaging:5 g
  • Price:$ 950
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:7-Bromo[1,2,4]triazolo[1,5-a]pyridine
  • Packaging:1 g
  • Price:$ 275
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:7-Bromo[1,2,4]triazolo[1,5-a]pyridine
  • Packaging:1g
  • Price:$ 388
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:7-Bromo[1,2,4]triazolo[1,5-a]pyridine 98%
  • Packaging:5g
  • Price:$ 945
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:7-Bromo[1,2,4]triazolo[1,5-a]pyridine 98%
  • Packaging:1g
  • Price:$ 275
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:7-Bromo[1,2,4]triazolo[1,5-a]pyridine 98%
  • Packaging:500mg
  • Price:$ 170
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:7-Bromo-[1,2,4]triazolo[1,5-a]pyridine 93%
  • Packaging:1g
  • Price:$ 150
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:7-Bromo-[1,2,4]triazolo[1,5-a]pyridine 93%
  • Packaging:500mg
  • Price:$ 100
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:7-Bromo-[1,2,4]triazolo[1,5-a]pyridine 95%
  • Packaging:100g
  • Price:$ 2725
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 3 Articles be found

FUSED RING HETEROARYL COMPOUNDS AS ALK4/5 INHIBITORS

-

, (2020/08/05)

The invention provides novel substituted heterocyclic compounds represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of ALK5 and/or ALK4 and are useful in the treatment of pulmonary fibrosis, NASH, obesity, diabetes, cancers and other inflammation.

SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF

-

Page/Page column 124, (2010/04/03)

The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.

Process route upstream and downstream products

Process route

N-(4-bromopyridin-2-yl)-N'-hydroxyimidoformamide hydrochloride

N-(4-bromopyridin-2-yl)-N'-hydroxyimidoformamide hydrochloride

7-bromo-[1,2,4]triazolo[1,5-a]pyridine
1053655-66-5

7-bromo-[1,2,4]triazolo[1,5-a]pyridine

Conditions
Conditions Yield
N-(4-bromopyridin-2-yl)-N'-hydroxyimidoformamide hydrochloride; With trifluoroacetic anhydride; In tetrahydrofuran; at 20 ℃; Cooling with ice;
With sodium hydrogencarbonate; In tetrahydrofuran; water;
76%
(E)-N-(4-bromopyridin-2-yl)-N'-hydroxyformimidamide

(E)-N-(4-bromopyridin-2-yl)-N'-hydroxyformimidamide

7-bromo-[1,2,4]triazolo[1,5-a]pyridine
1053655-66-5

7-bromo-[1,2,4]triazolo[1,5-a]pyridine

Conditions
Conditions Yield
With TFAA; In tetrahydrofuran; at 0 - 50 ℃; for 2h;
83%
formic acid
64-18-6

formic acid

1,2-diamino-4-bromopyridin-1-ium-2,4,6-trimethylbenzenesulfonate
1202704-61-7

1,2-diamino-4-bromopyridin-1-ium-2,4,6-trimethylbenzenesulfonate

7-bromo-[1,2,4]triazolo[1,5-a]pyridine
1053655-66-5

7-bromo-[1,2,4]triazolo[1,5-a]pyridine

Conditions
Conditions Yield
formic acid; 1,2-diamino-4-bromopyridin-1-ium-2,4,6-trimethylbenzenesulfonate; With hydrogenchloride; In water; for 15h; Reflux;
With sodium hydrogencarbonate; In water;
84%
2-amino-4-bromopyridine
84249-14-9

2-amino-4-bromopyridine

7-bromo-[1,2,4]triazolo[1,5-a]pyridine
1053655-66-5

7-bromo-[1,2,4]triazolo[1,5-a]pyridine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: chloroform / 3 h / 20 °C
2: hydrogenchloride / water / 15 h / Reflux
With hydrogenchloride; In chloroform; water;
Multi-step reaction with 2 steps
1.1: isopropyl alcohol / 3 h / Reflux
1.2: 50 °C
2.1: TFAA / tetrahydrofuran / 2 h / 0 - 50 °C
With TFAA; In tetrahydrofuran; isopropyl alcohol;
(5R)-3-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one
700370-33-8

(5R)-3-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

7-bromo-[1,2,4]triazolo[1,5-a]pyridine
1053655-66-5

7-bromo-[1,2,4]triazolo[1,5-a]pyridine

(R)-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one
1202701-61-8

(R)-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

Conditions
Conditions Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 90 - 100 ℃; for 1.5h;
67%
7-bromo-[1,2,4]triazolo[1,5-a]pyridine
1053655-66-5

7-bromo-[1,2,4]triazolo[1,5-a]pyridine

(R)-3-(3-fluoro-4-(3,3,4,4-tetramethylborolan-1-yl)phenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

(R)-3-(3-fluoro-4-(3,3,4,4-tetramethylborolan-1-yl)phenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

(R)-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one
1202701-61-8

(R)-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

Conditions
Conditions Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; for 1h; Reflux;
67%
7-bromo-[1,2,4]triazolo[1,5-a]pyridine
1053655-66-5

7-bromo-[1,2,4]triazolo[1,5-a]pyridine

(S)-(N-3-(3-fluoro-4-(3,3,4,4-tetramethylborolan-1-yl)phenyl)-2-oxo-5-oxazolidinyl)methylacetamide

(S)-(N-3-(3-fluoro-4-(3,3,4,4-tetramethylborolan-1-yl)phenyl)-2-oxo-5-oxazolidinyl)methylacetamide

(S)-(N-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-2-oxo-5-oxazolidinyl)methylacetamide
1202701-54-9

(S)-(N-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-2-oxo-5-oxazolidinyl)methylacetamide

Conditions
Conditions Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; for 1h; Reflux;
74%
Trimethyl borate
121-43-7,63156-11-6

Trimethyl borate

7-bromo-[1,2,4]triazolo[1,5-a]pyridine
1053655-66-5

7-bromo-[1,2,4]triazolo[1,5-a]pyridine

[1,2,4]triazolo[1,5-a]pyridin-6-ylboronic acid
1201643-69-7

[1,2,4]triazolo[1,5-a]pyridin-6-ylboronic acid

Conditions
Conditions Yield
With tert.-butyl lithium; In tetrahydrofuran; hexane; toluene; at -78 - -15 ℃;
55%
7-bromo-[1,2,4]triazolo[1,5-a]pyridine
1053655-66-5

7-bromo-[1,2,4]triazolo[1,5-a]pyridine

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,2,4]triazolo[1,5-a]pyridine
1210048-18-2

7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,2,4]triazolo[1,5-a]pyridine

Conditions
Conditions Yield
tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine; In 1,4-dioxane; at 20 ℃; for 0.5h; Inert atmosphere;
7-bromo-[1,2,4]triazolo[1,5-a]pyridine; bis(pinacol)diborane; With potassium acetate; In 1,4-dioxane; at 80 ℃; Inert atmosphere;
With tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; tricyclohexylphosphine; In 1,4-dioxane; at 80 ℃; for 12h; Inert atmosphere;

Global suppliers and manufacturers

Global( 42) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:163
  • Country:China (Mainland)
  • BOC Sciences
  • Business Type:Trading Company
  • Contact Tel:1-631-485-4226
  • Emails:sales@bocsci.com
  • Main Products:41
  • Country:United States
  • Chemlyte Solutions
  • Business Type:Other
  • Contact Tel:+86-189 8945 5137
  • Emails:sales@chemlytesolutions.com
  • Main Products:197
  • Country:China (Mainland)
  • LEAP CHEM Co., Ltd.
  • Business Type:Trading Company
  • Contact Tel:0571-87317139
  • Emails:market15@leapchem.com
  • Main Products:88
  • Country:China (Mainland)
  • Bide Pharmatech Ltd
  • Business Type:Other
  • Contact Tel:021-61629020
  • Emails:sales@bidepharmatech.com
  • Main Products:1
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1053655-66-5
Post Buying Request Now
close
Remarks: The blank with*must be completed