105590-97-4

Basic information

• Product Name: H-GLU(OBZL)-OTBU HCL
• Synonyms: H-GLU(OBZL)-OTBU HCL;H-L-GLU(BZL)-OTBU HCL;H-L-GLU(OBZL)-OTBU HCL;L-GLUTAMIC ACID ALPHA-T-BUTYL-DELTA-BENZYL DIESTER HYDROCHLORIDE;L-GLUTAMIC ACID ALPHA-T-BUTYL-GAMMA-BENZYL-DIESTER HYDROCHLORIDE;L-GLUTAMIC ACID GAMMA-BENZYL ESTER ALPHA-T-BUTYL ESTER;GLUTAMIC ACID(OBZL)-OTBU HCL;GLUTAMIC ACID ALPHA-TERT-BUTYL-GAMMA-BENZYL DIESTER HYDROCHLORIDE
• CAS NO: 105590-97-4
• Molecular Formula: C₁₆H₂₃NO₄*ClH
• Molecular Weight: 329.82
• Mol File: 105590-97-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: DMSO, Methanol
• CAS DataBase Reference: H-GLU(OBZL)-OTBU HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLU(OBZL)-OTBU HCL(105590-97-4)
• EPA Substance Registry System: H-GLU(OBZL)-OTBU HCL(105590-97-4)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 105590-97-4(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Uses

Different sources of media describe the Uses of 105590-97-4 differently. You can refer to the following data:
1. L-Glutamic Acid 1-(1,1-Dimethylethyl) 5-(Phenylmethyl) Ester Hydrochloride, is a versatile building block in the peptide chemistry. It can be used in the synthesis of series of dynamic peptides.
2. H-Glu(obzl)-otbu HCl

Upstream product

• 1676-73-9 L-glutamic acid γ-benzyl ester 
• 115-11-7 isobutene 
• 540-88-5 acetic acid tert-butyl ester 

Downstream Products

• 1026987-94-9 (S)-5-(tert-butoxy)-4-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic acid 
• 536721-25-2 L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester 
• 862778-54-9 2-bis(tert-butoxycarbonylmethyl)aminopentanedioic acid 5-benzyl ester 1-tert-butyl ester 
• 1025029-48-4 5-benzyl 1-tert-butyl N-{[2-(trimethylsilyl)ethoxy]carbonyl}-L-glutamate 
• 105608-12-6 (S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester 
• 106496-85-9 (S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 
• 105590-81-6 (S)-2-{2-[2-((S)-2-{[(S)-1-(4-Chloro-benzoyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyrylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-pentanedioic acid 1-tert-butyl ester 5-methyl ester 
• 105590-98-5 dimethyl N-(4'-chlorobenzoyl)-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-glutamate 

Relevant articles and documents

Preparation method of glutamic acid-5-benzyl ester-1-tert-butyl ester hydrochloride

A preparation method of glutamic acid-5-benzyl ester-1-tert-butyl ester hydrochloride mainly solves the problem of operation difficulty in the synthesis method of the prior arts. A technical scheme is as below: the preparation method of glutamic acid-5-benzyl ester-1-tert-butyl ester hydrochloride comprises the steps of: esterifying a starting material of glutamic acid with benzyl alcohol, and purifying to obtain glutamic acid 5-benzyl ester; conducting a transesterification reaction on glutamic acid 5-benzyl ester and tert-butyl acetate under catalysis to obtain glutamic acid-5-benzyl ester-1-tert-butyl ether; and finally controlling the atmosphere with ether hydrochloric acid to an acidic state to obtain the glutamate 5-benzyl-1-t-butyl ester hydrochloride. The product can be used for the field of peptide synthesis.