1056162-06-1

Basic information

• Product Name: 1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine
• Synonyms: 1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine;2-(Trifluoromethyl)-3-pyridinemethanamine
• CAS NO: 1056162-06-1
• Molecular Formula: C7H7F3N2
• Molecular Weight: 176.1390896
• Mol File: 1056162-06-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 194℃
• Flash Point: 71℃
• Appearance: /
• Density: 1.293
• Storage Temp.: 2-8°C(protect from light)
• PKA: 7.42±0.29(Predicted)
• CAS DataBase Reference: 1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine(1056162-06-1)
• EPA Substance Registry System: 1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine(1056162-06-1)

Safety Data

• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 1056162-06-1(Hazardous Substances Data)

Usage

General Description

1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine is a chemical compound with the molecular formula C8H8F3N. It is a derivative of pyridine, a heterocyclic aromatic compound, and is characterized by the presence of a trifluoromethyl group on the pyridine ring. The chemical is classified as an amine due to the presence of an amino group (-NH2) attached to the pyridine ring. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds. The trifluoromethyl group also imparts unique chemical and physical properties to the compound, making it of interest in medicinal chemistry and drug discovery.

Upstream product

• 590371-58-7 3-bromo-2-(trifluoromethyl)pyridine 
• 870066-15-2 2-(trifluoromethyl)pyridine-3-carbonitrile 
• 959108-47-5 2-(trifluoromethyl)nicotinamide 

Relevant articles and documents

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound useful in the treatment of a neurodegenerative disorder and their combined use as a medicament, in particular for the treatment of neurodegenerative and/or cognitive disorders.

4,6-DIAMINONICOTINAMIDE COMPOUND

[Problem] The present invention provides a 4,6-diaminonicotinamide compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for treating diseases caused by undesirable and/or abnormal cytokine signal transduction. [Means for Solution] The present inventors have extensively studied compounds having a JAK3 inhibitory action, and as a result, they have found that a 4,6-diaminonicotinamide compound which is the compound of the present invention has an excellent JAK3 inhibitory action and is useful as an agent for preventing or treating diseases caused by undesirable and/or abnormal cytokine signal transduction, thereby completing the present invention.