105639-84-7

Basic information

• Product Name: 5-Oxa-9-thia-3-aza-4-phosphaundecane-11-sulfonic acid, 4-amino-1-chloro-3-(2-chloroethyl)-8-hydroxy-, 4-oxide
• CAS NO: 105639-84-7
• Molecular Formula: C9H21Cl2N2O6PS2
• Molecular Weight: 419.287
• Mol File: 105639-84-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Oxa-9-thia-3-aza-4-phosphaundecane-11-sulfonic acid, 4-amino-1-chloro-3-(2-chloroethyl)-8-hydroxy-, 4-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Oxa-9-thia-3-aza-4-phosphaundecane-11-sulfonic acid, 4-amino-1-chloro-3-(2-chloroethyl)-8-hydroxy-, 4-oxide(105639-84-7)
• EPA Substance Registry System: 5-Oxa-9-thia-3-aza-4-phosphaundecane-11-sulfonic acid, 4-amino-1-chloro-3-(2-chloroethyl)-8-hydroxy-, 4-oxide(105639-84-7)

Safety Data

• Hazardous Substances Data: 105639-84-7(Hazardous Substances Data)

Upstream product

• 84210-72-0 cis-Mosfosfamide 
• 19767-45-4 mesna 
• 61903-29-5 cis-4-hydroxycyclophosphamide 

Relevant articles and documents

Activation Mechanisms of Mafosfamide and the Role of Thiols in Cyclophosphamide Metabolism

cis-Mafosfamide (cis-5) (ASTA Z7557), a stable analogue of cis-4-hydroxycyclophosphamide (cis-2), undergoes rapid decomposition in aqueous phosphate buffer or plasma at pH 7.4 and 37 deg C.The reaction kinetics of cis-5 are complex, and trans-mafosfamide (trans-5) and cis-2 are produced and subsequently disappear over the course of the reaction.The rates of decomposition of cis-5 as well as cis-2 were much faster in plasma than in buffer.The cis-trans isomerization of cis-5 occured by a specific-base-catalyzed process via iminocyclophosphamide (8) as a transient intermediate.In contrast, formation of cis- and trans-mafosfamide (5) from cis-2 and MESNA (sodium 2-mercaptoethanesulfonate) proceeded by an acid-catalyzed process via the hemithioacetal intermediate (6).The significance of these findings with respect to cyclophosphamide metabolism is discussed.