10564-00-8

Basic information

• Product Name: 4-(2-furyl)-4-oxobutanoic acid
• Synonyms: 4-(2-furyl)-4-oxobutanoic acid
• CAS NO: 10564-00-8
• Molecular Formula: C₈H₈O₄
• Molecular Weight: 168.15
• Mol File: 10564-00-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 363.2°C at 760 mmHg
• Flash Point: 173.5°C
• Appearance: /
• Density: 1.279g/cm³
• Vapor Pressure: 6.51E-06mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: 4-(2-furyl)-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-furyl)-4-oxobutanoic acid(10564-00-8)
• EPA Substance Registry System: 4-(2-furyl)-4-oxobutanoic acid(10564-00-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 10564-00-8(Hazardous Substances Data)

Usage

General Description

4-(2-furyl)-4-oxobutanoic acid is a chemical compound with the molecular formula C8H8O4. It is a derivative of furan and is commonly used in the synthesis of pharmaceuticals and agrochemicals. 4-(2-furyl)-4-oxobutanoic acid has a potent biological activity and can function as an antifungal and antibacterial agent. It is also known for its potential in the treatment of cancer and various inflammatory diseases. Additionally, 4-(2-furyl)-4-oxobutanoic acid has been studied for its antioxidant properties, making it a promising candidate for the development of novel therapeutic applications. Overall, this compound exhibits a wide range of potential uses in various fields of medicine and biotechnology.

InChI:InChI=1/C8H8O4/c9-6(3-4-8(10)11)7-2-1-5-12-7/h1-2,5H,3-4H2,(H,10,11)

Upstream product

• 54016-69-2 4-furan-2-yl-4-oxo-butyric acid ethyl ester 
• 98188-16-0 3-(2-Furoyl)propionsaeure-methylester 
• 110-00-9 furan 
• 108-30-5 succinic acid anhydride 
• 1026377-06-9 2-(Furan-2-carbonyl)-succinic acid 1-tert-butyl ester 4-ethyl ester 
• 170115-18-1 tert-butyl 3-(furan-2-yl)-3-oxopropanoate 

Relevant articles and documents

Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3

In this work we report a design, synthesis, and detailed functional characterization of unique strongly biased allosteric agonists of CXCR3 that contain tetrahydroisoquinoline carboxamide cores. Compound 11 (FAUC1036) is the first strongly biased allosteric agonist of CXCR3 that selectively induces weak chemotaxis and leads to receptor internalization and the β-arrestin 2 recruitment with potency comparable to that of the chemokine CXCL11 without any activation of G proteins. A subtle structural change (addition of a methoxy group, 14 (FAUC1104)) led to a contrasting biased allosteric partial agonist that activated solely G proteins, induced chemotaxis, but failed to induce receptor internalization or β-arrestin 2 recruitment. Concomitant structure-activity relationship studies indicated very steep structure-activity relationships, which steer the ligand bias between the β-arrestin 2 and G protein pathway. Overall, the information presented provides a powerful platform for further development and rational design of strongly biased allosteric agonists of CXCR3.

AGONISTS OF THE CHEMOKINE RECEPTOR CXCR3

The present invention relates to agonists of the chemokine receptor CXCR3, methods of their synthesis and uses thereof.

Chemical and biological studies of nakiterpiosin and nakiterpiosinone

Nakiterpiosin and nakiterpiosinone are two related C-nor-D-homosteroids isolated from the sponge Terpios hoshinota that show promise as anticancer agents. We have previously described the asymmetric synthesis and revision of the relative configuration of