105640-07-1Relevant articles and documents
Preparation method of 4-(4-hydroxyphenyl) cyclohexanone
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Paragraph 0068; 0076-0077, (2019/08/01)
The invention relates to the technical field of chemical synthesis, in particular to a preparation method of 4-(4-hydroxyphenyl) cyclohexanone. According to the preparation method, p-bromophenol is used as a raw material, a Grignard reagent is prepared through hydroxyl protection and Grignard reaction, then the prepared Grignard reagent is utilized to couple with 1,4-cyclohexanedione monoethyleneglycol ketal, then the product is dehydrated to obtain alkene, and double protecting groups are removed after hydrogenation to prepare a target product, namely, 4-(4-hydroxyphenyl) cyclohexanone. Thepreparation method of 4-(4-hydroxyphenyl) cyclohexanone, provided by the invention, has the advantages of reasonable process design, high yield and low production cost; the prepared 4-(4-hydroxyphenyl) cyclohexanone is a white solid, the HPLC content is more than 99.5%, the total yield of the product can reach 75-80%, and the raw materials are easy to obtain; and the method has simple operation and high safety, and realizes industrial production of 4-(4-hydroxyphenyl) cyclohexanone.
Method for synthesizing 4-(4'-hydroxy phenyl) cyclohexanone
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Paragraph 0001-0005, (2017/06/24)
According to the background: 4-(4'-hydroxy phenyl) cyclohexanone is an important liquid crystal monomer, a medicine intermediate, a chemical raw material intermediate, a macromolecule intermediate, an antioxidant and the like. Along with rapid development of the crystal liquid and medicine industries in recent years, the demand on 4-(4'-hydroxy phenyl) cyclohexanone (I) is greatly increased; because of palladium-charcoal hydrogenation, a conventional process generally has defects of being large in environment pollution, poor in selectivity, low in yield, high in cost and the like. Aiming at the problems, the invention provides a novel process to solve the problems. Key points of the novel process are that firstly, an aluminum-nickel alloy is adopted to replace palladium of a heavy metal catalyst, so that pollution caused by heavy metals can be avoided; secondly, the cis/trans-selectivity can be up to 70%, the total yield can be up to 50%, the yield of a product is increased to a very large extent, and the production cost can be lowered.
Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists
Zhang, Xuqing,Hufnagel, Heather,Markotan, Thomas,Lanter, James,Cai, Chaozhong,Hou, Cuifen,Singer, Monica,Opas, Evan,McKenney, Sandra,Crysler, Carl,Johnson, Dana,Sui, Zhihua
, p. 5577 - 5582 (2011/10/09)
A series of 4-azetidinyl-1-aryl-cyclohexanes as potent CCR2 antagonists with high selectivity over activity for the hERG potassium channel is discovered through divergent SARs of CCR2 and hERG.