105648-24-6

Basic information

• Product Name: 3,5-Pyridinedicarbonitrile, 6-amino-4-(4-bromophenyl)-1,2-dihydro-2-thioxo-
• CAS NO: 105648-24-6
• Molecular Formula: C13H7BrN4S
• Molecular Weight: 331.195
• Mol File: 105648-24-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarbonitrile, 6-amino-4-(4-bromophenyl)-1,2-dihydro-2-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarbonitrile, 6-amino-4-(4-bromophenyl)-1,2-dihydro-2-thioxo-(105648-24-6)
• EPA Substance Registry System: 3,5-Pyridinedicarbonitrile, 6-amino-4-(4-bromophenyl)-1,2-dihydro-2-thioxo-(105648-24-6)

Safety Data

• Hazardous Substances Data: 105648-24-6(Hazardous Substances Data)

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 1122-91-4 4-bromo-benzaldehyde 
• 2826-24-6 4-bromobenzylidenemalononitrile 
• 68029-54-9 3-(4-bromophenyl)-2-cyanoprop-2-enethioamide 
• 125219-60-5 2,6-diamino-4-(4-bromophenyl)-4H-thiopyran-3,5-dicarbonitrile 
• 95639-02-4 3-(4-Bromo-phenyl)-2,4,4-tricyano-but-3-enethioic acid amide 

Downstream Products

• 208254-30-2 2-[6-Amino-4-(4-bromo-phenyl)-3,5-dicyano-pyridin-2-ylsulfanyl]-acetamide 
• 208254-37-9 2-[6-Amino-4-(4-bromo-phenyl)-3,5-dicyano-pyridin-2-ylsulfanyl]-N-(4-bromo-phenyl)-acetamide 
• 208254-28-8 2-Amino-4-(4-bromo-phenyl)-6-[2-(4-bromo-phenyl)-2-oxo-ethylsulfanyl]-pyridine-3,5-dicarbonitrile 
• 208254-29-9 2-Amino-4-(4-bromo-phenyl)-6-[2-(4-chloro-phenyl)-2-oxo-ethylsulfanyl]-pyridine-3,5-dicarbonitrile 

Relevant articles and documents

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: Parallel synthesis, bioactivity, and in vitro pharmacokinetics

2-Aminopyridine-3,5-dicarbonitrile compounds were previously identified as mimetics of dominant-negative prion protein mutants and inhibit prion replication in cultured cells. Here, we report findings from a comprehensive structure-activity relationship study of the 6-aminopyridine-3,5-dicarbonitrile scaffold. We identify compounds with significantly improved bioactivity (approximately 40-fold) against replication of the infectious prion isoform (PrPSc) and suitable pharmacokinetic profiles to warrant evaluation in animal models of prion disease.

CONDENCED PYRIDINES. COMMUNICATION 4. THE MICHAEL REACTION IN THE SYNTHESIS OF SUBSTITUTED 3-CYANOPYRIDINE-2(1H)-THIONES

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