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1056555-46-4

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1056555-46-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1056555-46-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,6,5,5 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1056555-46:
(9*1)+(8*0)+(7*5)+(6*6)+(5*5)+(4*5)+(3*5)+(2*4)+(1*6)=154
154 % 10 = 4
So 1056555-46-4 is a valid CAS Registry Number.

1056555-46-4Relevant articles and documents

Identification of a new biaryl scaffold generating potent renin inhibitors

Lacombe, Patrick,Aspiotis, Renée,Bayly, Christopher,Chen, Austin,Dubé, Daniel,Fortin, Réjean,Gallant, Michel,Juteau, Hélne,Liu, Suzanna,McKay, Dan,Roy, Patrick,Wu, Tom

scheme or table, p. 5822 - 5826 (2010/12/19)

The discovery and SAR of a series of potent renin inhibitors possessing a novel biaryl scaffold are described herein. Molecular modeling revealed that the cyclopropylamide spacer present in 1 can be replaced by a simple, substituted aromatic ring such as

RENIN INHIBITORS

-

Page/Page column 82, (2008/06/13)

The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds. These novel renin inhibitors are used in treating cardiovascular events and renal insufficiency.

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