105685-06-1Relevant articles and documents
SALT OF CYCLOHEXANE DERIVATIVE
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Paragraph 0117-0119, (2021/10/11)
The present invention provides a maleate, phosphate, sulfate, hydrochloride of a cyclohexane derivative, N′-[trans-4-[2-[7-(benzo[b]thiophene)-7-piperazinyl]ethyl]cyclohexyl]-N,N-dimethylurea, as shown in Formula I and crystal forms thereof. The crystal forms have low hygroscopicity and good stability and are convenient for long-term storage and transportation; or the crystal forms have a long half-life in vivo, high bioavailability and small individual difference, and thus have obvious clinical application advantages.
Preparation method of benzothiophene derivative
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, (2020/07/02)
The invention provides a preparation method of a benzothiophene derivative, which comprises the following steps: reacting a compound shown as a formula 2 with dimethylamine under the conditions of anorganic solvent, an acid-binding agent and an additive to obtain a compound shown as a formula 1, namely the benzothiophene derivative. The preparation method provided by the invention is a benzothiophene derivative which is simple in reaction, mild in condition, few in reaction steps, few in reaction byproducts, simple in aftertreatment, high in yield, high in purity and easy for industrial production.
Preparation method of 7-piperazinyl benzothiophene or salt thereof
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, (2020/05/14)
The invention discloses a preparation method of 7-piperazinyl benzothiophene or salt thereof, comprising the following steps: (1) carrying out substitution ring closing reaction on a compound 3 and acompound 4 to obtain a compound 5; (2) carrying out hydr
