105686-75-7

Basic information

• Product Name: 3H-1,2,4-Triazole-3-thione, 4-amino-2,4-dihydro-5-(3-nitrophenyl)-
• CAS NO: 105686-75-7
• Molecular Formula: C8H7N5O2S
• Molecular Weight: 237.242
• Mol File: 105686-75-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3H-1,2,4-Triazole-3-thione, 4-amino-2,4-dihydro-5-(3-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-1,2,4-Triazole-3-thione, 4-amino-2,4-dihydro-5-(3-nitrophenyl)-(105686-75-7)
• EPA Substance Registry System: 3H-1,2,4-Triazole-3-thione, 4-amino-2,4-dihydro-5-(3-nitrophenyl)-(105686-75-7)

Safety Data

• Hazardous Substances Data: 105686-75-7(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 618-94-0 3-nitrobenzoic acid hydrazide 
• 121-92-6 3-nitrobenzoic acid 
• 41421-07-2 5-(3-nitrophenyl)-1,3,4-oxadiazole-2-thiol 
• 618-95-1 methyl 3-nitrobenzoate 
• 618-98-4 ethyl 3-nitrobenzoate 

Downstream Products

• 1262223-06-2 6-((1H-benzo[d][1,2,3]triazol-1-yl)methyl)-3-(3-nitrophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 

Relevant articles and documents

Study on the intramolecular Mannich reaction of 4-amino-3-aryl-2,3- dihydrogen-5-mercapto-1,2,4-triazoles

Seventeen novel fused heterocycles have been prepared by the intramolecular Mannich reaction of 4-amino-3-aryl-5-mercapto-1,2,4-triazole with aldehydes in the presence of acid, Yield: 32 ~ 90%. These compounds were screened for their antimicrobial activities.

Synthesis, characterization and antifungal evaluation of 5-substituted-4-amino-1,2,4-triazole-3-thioesters

A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole-2-thiols and 5-substituted-1,3,4-oxadiazole-2- thioesters. Finally the target compounds were obtained by refluxing 5-substituted-1,3,4-oxadiazole-2-thioesters in the presence of hydrazine hydrate and absolute alcohol. The structures of the synthesized compounds were established by physicochemical and spectroscopic methods. The synthesized compounds were evaluated for their in vitro antifungal activity. Some of the evaluated compounds possessed significant antifungal activity as compared to a terbinafine standard.

Synthesis of some novel 3-Alkyl/aryl-6-((1H-benzo[d][1,2,3]triazol-1-yl) methyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

(Chemical Equation Presented) A series of 3-alkyl/aryl substituted-6-((1H- benzo[d][1,2,3]triazol-1-yl)methyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadizoles 4a-m are prepared by the condensation of 3-alkyl/aryl substituted-4-amino-5- mercapto-1,2,4-triazoles 2a-m with benzotriazole-1-yl acetic acid 3 through a single step reaction. The structures of all newly synthesized compounds are established on the basis of their IR, 1H NMR, and elemental analyses data. Two selected compounds 4l and 4m are investigated for their analgesic and anti-inflammatory activities; they showed weak anti-inflammatory activity and no analgesic activity.