105706-75-0

Basic information

• Product Name: 1-CBZ-2-HYDROXYMETHYL-PIPERIDINE
• Synonyms: 2-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;1-CBZ-2-HYDROXYMETHYL-PIPERIDINE;Benzyl 2-(hydroxymethyl) piperidine-1-Carboxylate;N-Benzyloxycarbonyl-2-piperidineMethanol;1-Cbz-2-piperidineMethanol
• CAS NO: 105706-75-0
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Product Categories: pharmacetical
• Mol File: 105706-75-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 396.374 °C at 760 mmHg
• Flash Point: 193.52 °C
• Appearance: /
• Density: 1.163 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-CBZ-2-HYDROXYMETHYL-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CBZ-2-HYDROXYMETHYL-PIPERIDINE(105706-75-0)
• EPA Substance Registry System: 1-CBZ-2-HYDROXYMETHYL-PIPERIDINE(105706-75-0)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• Hazardous Substances Data: 105706-75-0(Hazardous Substances Data)

Usage

General Description

1-CBZ-2-HYDROXYMETHYL-PIPERIDINE is a chemical compound with a molecular formula C16H23NO3. It is an intermediate in the synthesis of pharmaceutical compounds and is widely used in the pharmaceutical industry. 1-CBZ-2-HYDROXYMETHYL-PIPERIDINE has applications in the production of various drugs, including antihistamines and antipsychotic medications. Its chemical structure contains a piperidine ring with a hydroxymethyl group and a carboxybenzyl (CBZ) protective group, making it a versatile building block in organic synthesis. Overall, 1-CBZ-2-HYDROXYMETHYL-PIPERIDINE plays an essential role in the development and production of medicines for various therapeutic applications.

InChI:InChI=1/C14H19NO3/c16-10-13-8-4-5-9-15(13)14(17)18-11-12-6-2-1-3-7-12/h1-3,6-7,13,16H,4-5,8-11H2

Upstream product

• 180609-56-7 1-benzoxycarbonyl-2-methoxycarbonylpiperidine 
• 501-53-1 benzyl chloroformate 
• 3433-37-2 piperidin-2-ylmethanol 
• 35677-83-9 methyl pipecolinate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 135938-63-5 2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine 
• 1072344-35-4 benzyl 2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine-1-carboxylate 
• 4043-87-2 pipecolic Acid 
• 28697-07-6 N-benzyloxycarbonyl D/L-pipecolinic acid 

Downstream Products

• 212557-00-1 (S)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester 
• 18881-13-5 (+)-coniceine 
• 139894-04-5 hexahydro-indolizin-3-one 
• 28697-11-2 (S)-1-(carbobenzyloxy)-2-piperidinecarboxylic acid 
• 212556-95-1 (S)-N-(benzyloxycarbonyl)-2-formylpiperidine 
• 212556-96-2 (Z)-benzyl 2-(prop-1-enyl)piperidine-1-carboxylate 
• 212556-97-3 (S)-2-((E)-2-Methoxycarbonyl-vinyl)-piperidine-1-carboxylic acid benzyl ester 
• 3105-95-1 pipecolinic acid 
• 1072344-41-2 benzyl 2-[(2-tert-butoxy-2-oxoethoxy)methyl]piperidine-1-carboxylate 
• 1072344-57-0 ((1-[(2-cyanophenyl)sulfonyl]piperidin-2-yl)methoxy)acetic acid 
• 1072344-54-7 tert-butyl ({1-[(2-cyanophenyl)sulfonyl]piperidin-2-yl}methoxy)acetate 
• 1353971-44-4 C₁₅H₂₂N₂O₂ 
• 664364-53-8 benzyl 2-(methoxymethoxymethyl)-1-piperidinecarboxylate 
• 154499-13-5 benzyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate 

Relevant articles and documents

The Synthesis of 1-Methyl-6,7,8,8a-tetrahydro-5H-indolizin-3-one by the Palladium-Catalyzed Cyclization of N-Bromoacetyl-2-vinylpiperidine

N-Bromoacetyl-2-vinylpiperidine underwent cyclizalion to give indolizidine derivative in the presence of a base and a catalytic amount of palladium trifluoroacetate.

Pyrrolidinic and piperidinic ring fission by conjugate elimination

Treating N-substituted pyrrolidines and piperidines bearing an allylic chain α to the nitrogen with strong bases leads to the opening of the heterocycle and provides 1,3-dienes disubstituted with an alkoxy and an aminoalkyl chain. The effects of the base and the solvent have been studied, as well as the influence of the ring size and the nitrogen substituent. The results obtained suggest a possible pre-chelation of the base cation before the deprotonation.

NEW BRADYKININ B1 ANTAGONISTS

The invention relates to compounds of formula (I), wherein R1 to R5 and X1 to X4, n and m have the meaning as cited in the description and the claims. Said compounds are useful as Bradykinin B1 antagonists. The

FUSED BENZENE DERIVATIVE AND USE

The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3' (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5' (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.