105706-76-1

Basic information

• Product Name: 1-CBZ-PIPERIDINE-2-ALDEHYDE
• Synonyms: N-CBZ-2-FORMYLPIPERIDINE;1-CBZ-2-FORMYLPIPERIDINE;N-CBZ-PIPERIDINE-2-CARBALDEHYDE;Benzyl 2-formylpiperidine-1-carboxylate;1-Cbz-2-Piperidinecarboxaldehyde;2-Formylpiperidine-1-carboxylic acid benzyl ester;N-Benzyloxycarbonyl-2-piperidinecarboxaldehyde;1-Piperidinecarboxylic acid, 2-forMyl-, phenylMethyl ester
• CAS NO: 105706-76-1
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.29
• Mol File: 105706-76-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 384.503 °C at 760 mmHg
• Flash Point: 186.341 °C
• Appearance: /
• Density: 1.222 g/cm³
• Vapor Pressure: 4.07E-06mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: 2-8°C
• PKA: -3.02±0.40(Predicted)
• CAS DataBase Reference: 1-CBZ-PIPERIDINE-2-ALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CBZ-PIPERIDINE-2-ALDEHYDE(105706-76-1)
• EPA Substance Registry System: 1-CBZ-PIPERIDINE-2-ALDEHYDE(105706-76-1)

Safety Data

• Hazardous Substances Data: 105706-76-1(Hazardous Substances Data)

Usage

Uses

1-Cbz-piperidine-2-aldehyde is used as a reactant in the kinetic resolution of racemic amino aldehydes via copper(II)/(R,R)-Ph-BOX complex catalyzed oxidation with N-iodosuccinimide.

InChI:InChI=1/C14H17NO3/c16-10-13-8-4-5-9-15(13)14(17)18-11-12-6-2-1-3-7-12/h1-3,6-7,10,13H,4-5,8-9,11H2

Upstream product

• 105706-75-0 1-benzyloxycarbonyl-2-hydroxymethylpiperidine 
• 28697-07-6 N-benzyloxycarbonyl D/L-pipecolinic acid 
• 501-53-1 benzyl chloroformate 
• 4043-87-2 pipecolic Acid 

Downstream Products

• 39945-51-2 benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate 
• 143321-98-6 ethyl-3-(N-benzyloxycarbonylpiperid-2-yl)-2-propenoate 
• 1229722-37-5 ethyl 3-(N-benzyloxycarbonylpyrrolin-2-yl)-2-propenoate 
• 1595280-69-5 (E)-benzyl-2-(4-diazo-3-oxobut-1-en-1-yl)piperidine-1-carboxylate 
• 1595280-70-8 (E)-benzyl 2-(4-(benzylamino)-4-oxobut-1-en-1-yl)piperidine-1-carboxylate 
• 1595280-76-4 (E)-benzyl 2-(4-oxo-4-(phenylamino)but-1-en-1-yl)piperidine-1-carboxylate 
• 1595280-77-5 (E)-benzyl 2-(4-(cyclohexylamino)-4-oxobut-1-en-1-yl)piperidine-1-carboxylate 
• 1595280-78-6 (E)-benzyl 2-(4-(diallylamino)-4-oxobut-1-en-1-yl)piperidine-1-carboxylate 
• 1108739-05-4 (2S)-N-(benzyloxycarbonyl)piperidine-2-carboxaldehyde dimethylacetal 
• 60369-19-9 (2R)-N-(benzyloxycarbonyl)-2-(methoxycarbonyl)piperidine 
• 105706-78-3 N-benzyloxycarbonyl-2-vinylpiperidine 

Relevant articles and documents

Effecient kinetic resolution of racemic amino aldehydes by oxidation with N-iodosuccinimide

(Chemical Equation Presented) Selective recognition: The first efficient method for the kinetic resolution of racemic amino aldehydes (see scheme, PG=protecting group) is based on a copper(II)/(R,R)-Ph-BOX complex. The coordinated amino aldehydes were tra

Methods for the stereoselective synthesis of substituted piperidines

One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will

The Synthesis of 1-Methyl-6,7,8,8a-tetrahydro-5H-indolizin-3-one by the Palladium-Catalyzed Cyclization of N-Bromoacetyl-2-vinylpiperidine

N-Bromoacetyl-2-vinylpiperidine underwent cyclizalion to give indolizidine derivative in the presence of a base and a catalytic amount of palladium trifluoroacetate.