1057384-02-7Relevant articles and documents
Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents
Imamura, Keisuke,Tomita, Naoki,Kawakita, Youichi,Ito, Yoshiteru,Ono, Kouji,Nii, Noriyuki,Miyazaki, Tohru,Yonemori, Kazuko,Tawada, Michiko,Sumi, Hiroyuki,Satoh, Yoshihiko,Yamamoto, Yukiko,Miyahisa, Ikuo,Sasaki, Masako,Satomi, Yoshinori,Hirayama, Megumi,Nishigaki, Ryuichi,Maezaki, Hironobu
, p. 3768 - 3779 (2017)
A lead compound A was identified previously as an stearoyl coenzyme A desaturase (SCD) inhibitor during research on potential treatments for obesity. This compound showed high SCD1 binding affinity, but a poor pharmacokinetic (PK) profile and limited chem