10574-70-6

Basic information

• Product Name: 3-(4-bromophenyl)-2-sulfanylidene-thiazolidin-4-one
• Synonyms: 3-(4-bromophenyl)-2-sulfanylidene-thiazolidin-4-one;3-(4-BroMophenyl)-2-thioxo-4-thiazolidinone, 95%
• CAS NO: 10574-70-6
• Molecular Formula: C₉H₆BrNOS₂
• Molecular Weight: 288.18404
• Mol File: 10574-70-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 386.7°C at 760 mmHg
• Flash Point: 187.7°C
• Appearance: /
• Density: 1.83g/cm³
• Vapor Pressure: 3.47E-06mmHg at 25°C
• Refractive Index: 1.775
• CAS DataBase Reference: 3-(4-bromophenyl)-2-sulfanylidene-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-bromophenyl)-2-sulfanylidene-thiazolidin-4-one(10574-70-6)
• EPA Substance Registry System: 3-(4-bromophenyl)-2-sulfanylidene-thiazolidin-4-one(10574-70-6)

Safety Data

• Hazardous Substances Data: 10574-70-6(Hazardous Substances Data)

Usage

Thiazolidin-4-one derivative

Contains a five-membered heterocyclic compound with a sulfur atom

Bromophenyl group

Benzene ring substituted with a bromine atom

Potential pharmacological activities

Anti-inflammatory, antimicrobial, antitumor properties
Specific properties may vary depending on context of application (research or industry)

InChI:InChI=1/C9H6BrNOS2/c10-6-1-3-7(4-2-6)11-8(12)5-14-9(11)13/h1-4H,5H2

Upstream product

• 6326-83-6 bis(carboxymethyl)trithiocarbonate 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 52030-77-0 3-(4-bromophenyl)-1,3-thiazolidine-2,4-dione 
• 32092-07-2 3-(4-bromo-phenyl)-5-(2,3-dimethoxy-benzylidene)-2-thioxo-thiazolidin-4-one 
• 32092-11-8 3-(4-bromo-phenyl)-5-(2-nitro-benzylidene)-2-thioxo-thiazolidin-4-one 
• 32092-01-6 3-(4-bromo-phenyl)-5-(3-methyl-benzylidene)-2-thioxo-thiazolidin-4-one 
• 32092-08-3 3-(4-bromo-phenyl)-5-(2,4-dimethoxy-benzylidene)-2-thioxo-thiazolidin-4-one 
• 15246-93-2 3-(4-bromo-phenyl)-2-thioxo-thiazolidine-4,5-dione 5-phenylhydrazone 
• 32091-99-9 3-(4-bromo-phenyl)-5-(4-chloro-benzylidene)-2-thioxo-thiazolidin-4-one 
• 32254-21-0 3-(4-bromo-phenyl)-5-(4-methyl-benzylidene)-2-thioxo-thiazolidin-4-one 
• 10505-47-2 3'-(4-bromo-phenyl)-3-methyl-2'-thioxo-tetrahydro-[2,5']bithiazolyliden-4'-one 
• 32092-03-8 3-(4-bromo-phenyl)-5-(3,4-dimethyl-benzylidene)-2-thioxo-thiazolidin-4-one 

Relevant articles and documents

Design, synthesis and biological evaluation of 3-substituted 2,5-dimethyl-N-(3-(1H-tetrazol-5-yl)phenyl)pyrroles as novel potential HIV-1 gp41 inhibitors

Based on the structure of HIV-1 gp41 binding site for small-molecule inhibitors, optimization of lead 2 resulted in the discovery of a new series of 2,5-dimethyl-3-(5-(N-phenylrhodaninyl)methylene)-N-(3-(1H-tetrazol-5-yl)phenyl) pyrrole compounds with improved anti-HIV-1 activity. The most active compounds 13a and 13j exhibited significant potency against gp41 6-HB formation with IC50 values of 4.4 and 4.6 μM and against HIV-1 replication in the MT-2 cells with EC50 values of 3.2 and 2.2 μM, respectively, thus providing a new starting point to develop highly potent small-molecule HIV fusion inhibitors targeting gp41.