105742-66-3

Basic information

• Product Name: Pyrimidine, 4,5-dichloro-2,6-dimethyl-
• CAS NO: 105742-66-3
• Molecular Formula: C6H6Cl2N2
• Molecular Weight: 177.033
• Mol File: 105742-66-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Pyrimidine, 4,5-dichloro-2,6-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 4,5-dichloro-2,6-dimethyl-(105742-66-3)
• EPA Substance Registry System: Pyrimidine, 4,5-dichloro-2,6-dimethyl-(105742-66-3)

Safety Data

• Hazardous Substances Data: 105742-66-3(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 4,5-dichloro-2,6-dimethyl- is a chemical compound with the molecular formula C6H6Cl2N2. It is a member of the pyrimidine family, which is a heterocyclic organic compound that consists of a six-membered ring with four carbon atoms and two nitrogen atoms. This specific compound is distinguished by the presence of chlorine atoms at the 4th and 5th positions and methyl groups at the 2nd and 6th positions on the pyrimidine ring. It is used as a building block in the synthesis of pharmaceutical compounds and is also a common intermediate in the production of herbicides and pesticides. 4,5-dichloro-2,6-dimethyl-pyrimidine is considered to be stable under normal conditions and is not classified as hazardous, but proper handling and storage are still necessary to avoid any potential risks.

Upstream product

• 20551-34-2 5-chloro-2,6-dimethylpyrimidin-4-ol 

Downstream Products

• 127588-23-2 5-chloro-2,4-dimethyl-6-phenylpyrimidine 

Relevant articles and documents

Design, synthesis, and insecticidal/acaricidal evaluation of novel pyrimidinamine derivatives containing phenyloxazole moiety

A series of novel pyrimidinamine derivatives containing phenyloxazole moiety were designed and synthesized, and their structures were characterized by 1H NMR, MS, and elemental analyses. The bioassay results displayed that some compounds exhibited remarkable insecticidal activities against Aphis fabae and Tetranychus cinnabarinus. Especially, 5-chloro-6-ethyl-2-methyl-N-((2-(p-tolyl)oxazol-4-yl)methyl)pyrimidin-4-amine (9o) showed potent activity against A. fabae, superior to that of the commercial insecticide, imidacloprid. In addition, 5-chloro-6-ethyl-2-methyl-N-((2-(4-(trifluoromethyl)phenyl)oxazol-4-yl)methyl)pyrimidin-4-amine (9r) showed potent activities against T. cinnabarinus, inferior to that of the commercial insecticide spirotetramat. The structure–activity relationship study for the target compounds was also discussed.

Design, synthesis, insecticidal, and acaricidal activities of novel pyrimidinamine derivatives containing a biphenyl ether

A series of original pyrimidinamine derivatives containing a biphenyl ether moiety were designed and synthesized. Their structures were confirmed by 1H NMR, MS, and elemental analyses. Their insecticidal activities against lepidopteran and hemiptera insects and acaricidal activities were tested. The results of bioassay demonstrated that 9k showed the best activity (LC50 = 2.08 mg/L) against Tetranychus urticae, which is comparable with the positive control, spirotetramat (LC50 = 2.27 mg/L), and 9g showed better activity (LC50 = 0.52 mg/L) against Aphis fabae than the positive control, imidacloprid (LC50 = 1.02 mg/L), and relatively good activity (LC50 = 2.49 mg/L) against T urticae. Their structure-activity relationships indicated that both an ethyl group on the 4-position of the pyrimidine ring and alkyl chain as a para-substituent group of the benzene ring showed good biological activity.