10575-41-4Relevant articles and documents
A CONVENIENT SYNTHESIS OF ACETYLENIC KETONES FROM β-DIKETONES USING α,α-DIFLUOROALKYLAMINES AND FREEZE-DRIED POTASSIUM FLUORIDE
Kitazume, Tomoya,Ishikawa, Nobuo
, p. 1327 - 1328 (1980)
α,α-Difluoroalkylamines, such as 1-diethylamino-2-chloro-1,1,2-trifluoroethane (1) and 1-diethylamino-1,1,2,3,3,3-hexafluoropropane (2), were found to be useful dehydrating agents for the sysnthesis of acetylenic ketones from β-diketones in the presence o
Selective oxidation of unsaturated alcohols catalyzed by sodium nitrite and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone with molecular oxygen under mild conditions
Wang, Lianyue,Li, Jun,Yang, Hua,Lv, Ying,Gao, Shuang
experimental part, p. 790 - 794 (2012/02/16)
We have developed a simple and practical process for the oxidation of alcohols to the corresponding carbonyl compounds by using a low catalytic amount of DDQ, NaNO2 as a cocatalyst, and molecular oxygen as terminal oxidant. Nitric oxide generated in situ by NaNO2 in the presence of AcOH is essential for the realization of the catalytic cycle at room temperature. The practical utility of this catalytic process has been demonstrated in the gram-scale oxidation of cinnamyl alcohol.
N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists
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Page/Page column 29-30, (2010/11/30)
The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises administering to that subject a therapeutically effective amount of a compound of formula I: wherein, generally, Q is R1 is benzyl, phenyl, thiophene or imidazolyl optionally substituted with C1-4alkyl or halogen, such as methyl, fluorine or bromine; R2 is hydrogen or C1-4alkyl such as methyl; R3 is phenyl; R4 is hydrogen; R5 is hydrogen or C1-6alkylcarbonyl such as methylcarbonyl; X is —SO2— or —C(O)N(R2)SO2— where R2 is preferably hydrogen; Y is a bond, CH2 or Z1 where Z1 is —N(Rf)— in which Rf is C1-6alkylcarbonyl such as ethylcarbonyl; and R6 is phenyl, pyrazolyl, pyridyl, pyrimidinyl or benzimidazolonyl optionally substituted with one or two groups chosen from C1-6alkyl and benzyl, such as methyl, ethyl and benzyl; or a pharmaceutically acceptable salt thereof.