105751-18-6

Basic information

• Product Name: NEPSILON-FMOC-NALPHA-CBZ-L-LYSINE, 98
• Synonyms: NEPSILON-FMOC-NALPHA-CBZ-L-LYSINE, 98;N-Fmoc-N-benzyloxycarbonyl-L-lysine;N6-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysine
• CAS NO: 105751-18-6
• Molecular Formula: C₂₉H₃₀N₂O₆
• Molecular Weight: 502.5583
• EINECS: 200-659-6
• Product Categories: Amino Acids
• Mol File: 105751-18-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 101 °C
• Boiling Point: 592.66°C (rough estimate)
• Flash Point: 408.1 °C
• Appearance: white fine powder
• Density: 1.2418 (rough estimate)
• Vapor Pressure: 1.04E-23mmHg at 25°C
• Refractive Index: 1.5800 (estimate)
• Storage Temp.: Refrigerator (+4°C)
• CAS DataBase Reference: NEPSILON-FMOC-NALPHA-CBZ-L-LYSINE, 98(CAS DataBase Reference)
• NIST Chemistry Reference: NEPSILON-FMOC-NALPHA-CBZ-L-LYSINE, 98(105751-18-6)
• EPA Substance Registry System: NEPSILON-FMOC-NALPHA-CBZ-L-LYSINE, 98(105751-18-6)

Safety Data

• Hazardous Substances Data: 105751-18-6(Hazardous Substances Data)

Usage

Chemical Properties

white fine powder

InChI:InChI=1/C29H30N2O6/c32-27(33)26(31-29(35)36-18-20-10-2-1-3-11-20)16-8-9-17-30-28(34)37-19-25-23-14-6-4-12-21(23)22-13-5-7-15-24(22)25/h1-7,10-15,25-26H,8-9,16-19H2,(H,30,34)(H,31,35)(H,32,33)/p-1/t26-/m0/s1

Upstream product

• 2212-75-1 N₂-[(benzyloxy)carbonyl]-L-lysine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 88744-04-1 (9-fluorenyl)methyl pentafluorophenyl carbonate 

Downstream Products

• 1234549-11-1 S,S'-bis(2,4,6-trimethoxybenzyl) Nα-benzyloxycarbonyl-Nε-fluorenylmethoxycarbonyl-L-lysyl-D-tryptophanyl-L-leucyl-L-dithioaspartate 
• 151132-75-1 (S)-2-Benzyloxycarbonylamino-6-(bis-tert-butoxycarbonylmethyl-amino)-hexanoic acid 2-trimethylsilanyl-ethyl ester 
• 151132-72-8 2-(trimethylsilyl)ethyl N²-[(benzyloxy)carbonyl]-L-lysinate 
• 403736-61-8 [2-benzyloxycarbonylamino-6-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-hexanoylamino]-acetic acid tert-butyl ester 
• 403736-57-2 N_α-carbobenzyloxy-L-lysylglycin tert-butyl ester 
• 1101-84-4 N^(ε)-5-(dimethylamino)naphthalene-1-sulfonyl-L-lysine 
• 827021-73-8 N^(α)-benzyloxycarbonyl-N^(ε)-9-fluorenylmethyloxycarbonyl-L-lysine benzyl ester 
• 403736-53-8 N_α-carbobenzyloxy-N_ε-9-fluorenylmethoxycarbonyl-L-lysylglycin tert-butyl ester 
• 105751-16-4 Fmoc-Z-Lys-Pfp 
• 151132-68-2 (S)-2-Benzyloxycarbonylamino-6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 2-trimethylsilanyl-ethyl ester 

Relevant articles and documents

DRUG-LOADED EMULSION

The present invention relates to a drug-loaded emulsion, comprising a modified hydrophobic excipient having the following formula, a hydrophobic drug and a surfactant: where R is a hydrophobic natural compound or a hydrophobic synthetic compound with one to three hydroxyl groups (n=1-3); and R1 is an α-amino protecting group, and R2 is an amino acid side chain, wherein, when m=0, R is reacted with an amino acid derivative with a protecting group by esterification to form a hydrophobic excipient carrying the amino acid derivative with a protecting group; or when m=1, R is firstly introduced with an amino acid linking arm of different chain lengths (l=1, 2, 4, 6) via an ester group, and then introduced with an amino acid derivative with a protecting group.

Synthesis and evaluation of novel dipeptide-bound 1,2,4-thiadiazoles as irreversible inhibitors of guinea pig liver transglutaminase.

Herein we report the synthesis and evaluation of 14 novel peptides as potential irreversible inactivators of guinea pig liver transglutaminase (TGase). These peptides were designed to resemble Cbz-L-Gln-Gly, known to be a good TGase substrate, and to include a 1,2,4-thiadiazole group. The side chain length of the amino acid residue bearing the inhibitor group was also varied in order to permit investigation of this effect. Their inactivation rate constants were measured using a direct continuous spectrophotometric method and were found to vary between 0.330 to 0.89 microM(-1) min(-1).