105751-19-7

Basic information

• Product Name: FMOC-D-PIPECOLIC ACID
• Synonyms: (D)-N-(9-FLUORENYLMETHYLOXYCARBONYL)PIPECOLIC ACID;(D)-N-FMOC-PIPECOLIC ACID;FMOC-(R)-PIPECOLINIC ACID;FMOC-(R)-(+)-PIPERIDINE-2-CARBOXYLIC ACID;FMOC-(R)-PIPERIDINE-2-CARBOXYLIC ACID;FMOC-D-PIP-OH;FMOC-D-PIC(2)-OH;FMOC-D-HOMOPRO-OH
• CAS NO: 105751-19-7
• Molecular Formula: C₂₁H₂₁NO₄
• Molecular Weight: 351.4
• Mol File: 105751-19-7.mol
• Article Data: 19

Chemical Properties

• Melting Point: 150-151℃
• Boiling Point: 561.6 °C at 760 mmHg
• Flash Point: 293.5 °C
• Appearance: /
• Density: 1.293 g/cm³
• Vapor Pressure: 1.89E-13mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: 2-8°C
• CAS DataBase Reference: FMOC-D-PIPECOLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-PIPECOLIC ACID(105751-19-7)
• EPA Substance Registry System: FMOC-D-PIPECOLIC ACID(105751-19-7)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36/37/38-50/53
• Safety Statements: 26-36-61-60
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 105751-19-7(Hazardous Substances Data)

Usage

Uses

Reactant for racemic solid-phase preparation of human protease activated receptor 2 agonists and antagonistsAnalyte for urea-linked cinchona-calexarene hybrid type receptors for chromatographic enantiomer separation of carbamate-protected amino acidsCombinatorial reactant for assembly of alkylglycine library arrays by SPOT technique on cellulose membranes for identification of micromolar ligands for monoclonal antibodies

InChI:InChI=1/C21H21NO4/c23-20(24)19-11-5-6-12-22(19)21(25)26-13-18-16-9-3-1-7-14(16)15-8-2-4-10-17(15)18/h1-4,7-10,18-19H,5-6,11-13H2,(H,23,24)/t19-/m1/s1

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 15912-30-8 (2S)-2-piperidinecarboxylic acid L-tartrate 
• 88744-04-1 (9-fluorenyl)methyl pentafluorophenyl carbonate 
• 3105-95-1 pipecolinic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 15912-30-8 (R)-(+)-2-piperidinecarboxylic acid (+)-tartrate 
• 136552-06-2 N-(N-(9-fluorenyl)methoxycarbonyl)-L-azetidine-2-carboxylic acid 
• 4043-87-2 pipecolic Acid 
• 6940-78-9 4-chlorobutyl bromide 
• 1723-00-8 (R)-(+)-pipecolic acid 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 

Downstream Products

• 1013621-71-0 (S)-piperidine-1,2-dicarboxylic acid 2-[(R)-1-[3-(tert-butyl-dimethyl-silanoxy)-phenyl]-3-(3,4-dimethoxy-phenyl)-propyl] ester 1-(9H-fluoren-9-yl)methyl ester 
• 1316671-14-3 C₃₄H₃₇NO₆ 
• 1316671-16-5 (R)-N-(9-fluorenylmethoxycarbonyl)-(S)-pipecolinylphenyllactic acid 
• 1374119-61-5 1-((9H-fluoren-9-yl)methyl) 2-((R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl) (S)-piperidine-1,2-dicarboxylate 
• 1445604-11-4 C₄₃H₄₇NO₁₀ 
• 1445604-02-3 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(4-phenoxy-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid 
• 1445604-12-5 C₃₇H₄₁Cl₂NO₉ 
• 1445604-03-4 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(3,5-dichloro-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid 
• 195202-02-9 (S)-1-(9H-fluoren-9-yl)methyl 2-((R)-1-(3-(2-tert-butoxy-2-oxo-ethoxy) phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-1,2-dicarboxylate 

Relevant articles and documents

Synthesis of Shld Derivatives, Their Binding to the Destabilizing Domain, and Influence on Protein Accumulation in Transgenic Plants

A series of 35 analogues of Shld with modifications in the A-residue and the C-residues were prepared and investigated for binding to FKBP and GFP accumulation in transgenic plants. The modifications investigated explored variations that were supposedly i

Heterocyclic core analogs of a direct thrombin inhibitor

Thrombin is a serine protease that plays a key role in blood clotting. Pyrrolidine 1 is a potent thrombin inhibitor discovered at Merck several years ago. Seven analogs (2-8) of 1 in which the pyrrolidine core was replaced with various heterocycles were p

THROMBIN INHIBITORS

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: (I) or a pharmaceutically acceptable salt thereof, wherein Q is CH2, NR4, O, S, S(O) or S(O2