105752-35-0

Basic information

• Product Name: Ethanone, 1-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-
• CAS NO: 105752-35-0
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Mol File: 105752-35-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-(105752-35-0)
• EPA Substance Registry System: Ethanone, 1-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-(105752-35-0)

Safety Data

• Hazardous Substances Data: 105752-35-0(Hazardous Substances Data)

Upstream product

• 764-48-7 ethyleneglycol vinyl ether 
• 99-90-1 para-bromoacetophenone 
• 3609-53-8 methyl 4-acetylbenzoate 
• 676-58-4 methylmagnesium chloride 
• 14490-45-0 4-(2-methyl-1,3-dioxolan-2-yl)benzaldehyde 
• 78906-12-4 2-methyl-2-(4-hydoxymethylphenyl)-1,3-dioxolyn 
• 78906-11-3 2-methyl-2-(4-methoxycarbonylphenyl)-1,3-dioxolan 
• 4360-68-3 2-(4-bromophenyl)-2-methyl-1,3-dioxolane 
• 329006-00-0 2-[4-(1-hydroxyethyl)phenyl]-2-methyl-1,3-dioxolane 

Downstream Products

• 329006-05-5 (S)-2-(1-(4-acetylphenyl)ethyloxy)-1,3,2-dioxaphosphorinane 
• 108673-17-2 (R)-1-[4-(1-hydroxyethyl)phenyl]ethan-1-one 
• 185144-38-1 (S)-1-(4-(1-hydroxyethyl)phenyl)ethanone 

Relevant articles and documents

Palladium on Carbon-Catalyzed Chemoselective Oxygen Oxidation of Aromatic Acetals

The development of an unprecedented chemoselective transformation has contributed to forming a novel synthetic process for target molecules. Chemoselective oxidation of aromatic acetals has been accomplished using a reusable palladium on carbon catalyst under atmospheric oxygen conditions to form ester derivatives with tolerance of aliphatic acetals and ketals.

Hydrogen-bond-directed catalysis: Faster, regioselective and cleaner heck arylation of electron-rich olefins in alcohols

A general method for the regioselective Heck reaction of electronrich olefins is presented. Fast, highly regioselective Pd-catalysed α-arylation of electron-rich olefins, vinyl ethers (1a-d), hydroxyl vinyl ethers (1e,f), enamides (1g,h) and a substituted vinyl ether (1i) has been accomplished with a diverse range of aryl bromides (2a-r), for the first time, in cheap, green and easily available alcohols with no need for any halide scavengers or salt additives. The reaction proceeds with high efficiency, leading exclusively to the a-products, in 2-propanol and particularly in ethylene glycol. In the latter, the arylation can be catalysed at a palladium loading of 0.1 mol% and finish in as short a time as 0.5 h. The remarkable performance of the alcohol solvents in promoting a regiocontrol is attributed to their hydrogen-bond- donating capability, which is believed to facilitate the dissociation of halide anions from PdII, and hence, the generation of a key ionic Pd II-olefin intermediate responsible for the a product. This belief is further strengthened by the study of a benchmark arylation reaction in 21 different solvents. The study revealed that exclusive α-regioselective arylation takes place in almost all of the protic solvents, and there is a rough correlation between the α-arylation rates and the solvent parameter ETN. The method is simpler, cleaner and more general than those established thus far.

The Heck reaction of electron-rich olefins with regiocontrol by hydrogen-bond donors

No salt please: Halide scavengers AgOTf and TlOAc are not required for the Heck coupling of electron-rich olefins with aryl bromides and chlorides. Using ammonium additives, these reactions can be carried out in either an imidazolium ionic liquid or a common molecular solvent, thus furnishing 1,1′- disubstituted olefins in high yields with excellent regioselectivities. (Chemical Equation Presented).