106050-81-1

Basic information

• Product Name: 6-benzoxazolol
• Synonyms: 6-benzoxazolol;benzo[d]oxazol-6-ol;1,3-benzoxazol-6-ol
• CAS NO: 106050-81-1
• Molecular Formula: C₇H₅NO₂
• Molecular Weight: 135.1201
• Mol File: 106050-81-1.mol

Chemical Properties

• Melting Point: 179 °C
• Boiling Point: 270.0±13.0 °C(Predicted)
• Appearance: /
• Density: 1.378±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 8.33±0.40(Predicted)
• CAS DataBase Reference: 6-benzoxazolol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzoxazolol(106050-81-1)
• EPA Substance Registry System: 6-benzoxazolol(106050-81-1)

Safety Data

• Hazardous Substances Data: 106050-81-1(Hazardous Substances Data)

Upstream product

• 273-53-0 benzoxazole 
• 546-67-8 lead(IV) tetraacetate 
• 1253912-47-8 benzo[d]oxazol-6-ylboronic acid 
• 114980-26-6 6-methoxybenzoxazole 
• 40925-70-0 2-amino-5-methoxyphenol 
• 704-14-3 3-methoxy-6-nitro-phenol 
• 24057-28-1 pyridinium p-toluenesulfonate 
• 34781-86-7 4-aminoresorcinol hydrochloride 
• 122-51-0 orthoformic acid triethyl ester 
• 51-17-2 benzoimidazole 

Downstream Products

• 180716-26-1 [3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine 

Relevant articles and documents

Method for synthesizing benzoxazole through microwave radiation of benzamide compound in water phase

The invention discloses a method for synthesizing benzoxazole through microwave radiation of a benzamide compound in a water phase. The benzamide compound is added into the water phase under the microwave condition to be subjected to a cyclization reaction for generating the benzoxazole under the alkali condition, and the method for preparing the benzoxazole is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applied to a large number of functional groups, the yield is high, the number of by-products is small, and the method is easy to operate, safe, low in cost and environmentally friendly. (Please see the specifications for the formula).

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The invention discloses a method for catalytic oxidation of phenolic compounds fragrant boron class compound synthesis method, the flux in the solvent in the aqueous solution, under the action of alkali, adding hydrazine hydrate or acid hydrazides catalyst, catalytic oxidation fragrant boron class compound directly for the preparation of phenolic compound. The invention of the method of preparation of the phenol compound, the catalyst is a cheap hydrazine hydrate or hydrazine compound, the oxidizing agent is atmospheric pressure of air or oxygen, the reaction does not need good and activeness metal catalyst, is extensive and stable substrate, substrate-sensitive functional group compatibility good and wide range of application. In the optimized under the reaction conditions, the yield of the target product separation up to 99%. (by machine translation)

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Oxidations with Lead Tetraacetate. VI. Oxidations of Benzimidazoles, Benzoxazoles and Benzothiazoles

Benzimidazole is slowly oxidized in the imidazole ring by lead tetraacetate to benzimidazol-2(3H)-one, 1-acetylbenzimidazol-2(3H)-one and N,N'-(o-phenylene)bisacetamide.With excess oxidant, oxidation also occurs in the benzene ring at C5.Benzoxazole is much more reactive and gives a variety of products formed by oxidation of both rings.Benzothiazole is the least reactive system and suffers only minimal oxidation at C2 of the thiazole ring.