106114-47-0

Basic information

• Product Name: 1,3,8-Triazaspiro[4.5]decan-4-one, 3-(2-fluorobutyl)-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-
• CAS NO: 106114-47-0
• Molecular Formula: C27H33F2N3O2
• Molecular Weight: 469.575
• Mol File: 106114-47-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3,8-Triazaspiro[4.5]decan-4-one, 3-(2-fluorobutyl)-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,8-Triazaspiro[4.5]decan-4-one, 3-(2-fluorobutyl)-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-(106114-47-0)
• EPA Substance Registry System: 1,3,8-Triazaspiro[4.5]decan-4-one, 3-(2-fluorobutyl)-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-(106114-47-0)

Safety Data

• Hazardous Substances Data: 106114-47-0(Hazardous Substances Data)

Upstream product

• 1871-73-4 1-bromo-2-fluorobutane 
• 749-02-0 spiperone 

Relevant articles and documents

A Rapid and Efficient Method for the Fluoroalkylation of Amines and Amides. Development of a Method Suitable for Incorporation of the Short-Lived Positron Emitting Radionuclide Fluorine-18

We have described a two-step method for the preparation of fluoroalkyl-substituted amines and amides.The sequence involves fluoride ion displacement of a haloalkyl trifluoromethanesulfonate (triflate), followed by fluoroalkylation of the heteroatom system (amine or amide) by the fluoroalkyl halide.Alternatively, the fluoroalkyl halide can be prepared by halofluorination of a terminal olefin.These reactions have been used to prepare various fluoroalkyl derivatives of N-phenylpiperazine and N-fluoroalkyl derivatives of the neuroleptic agent spiperone (7).The sequence is rapid, convenient, and efficient, even when fluoride ion is the limiting reagent.Therefore, it is readily adaptable to the preparation of a variety of compounds labeled with the short half-life (t1/2 = 110 min) positron-emitting radionuclide fluorine-18.