106148-67-8Relevant articles and documents
Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii
Kopańska, Katarzyna,Najda, Andzelika,Zebrowska, Justyna,Chomicz, Lidia,Piekarczyk, Janusz,Myjak, Przemys?aw,Bretner, Maria
, p. 2617 - 2624 (2007/10/03)
Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5,6-dimethyl-1H-benzotriazole (11) and 5,6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine.