1062073-40-8

Basic information

• Product Name: 6-chloro-2-methoxy-N-(4-(piperidin-1-yl)phenyl)acridin-9-amine
• Synonyms: 6-chloro-2-methoxy-N-(4-(piperidin-1-yl)phenyl)acridin-9-amine
• CAS NO: 1062073-40-8
• Molecular Weight: 417.938
• Mol File: 1062073-40-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-methoxy-N-(4-(piperidin-1-yl)phenyl)acridin-9-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-methoxy-N-(4-(piperidin-1-yl)phenyl)acridin-9-amine(1062073-40-8)
• EPA Substance Registry System: 6-chloro-2-methoxy-N-(4-(piperidin-1-yl)phenyl)acridin-9-amine(1062073-40-8)

Safety Data

• Hazardous Substances Data: 1062073-40-8(Hazardous Substances Data)

Upstream product

• 2359-60-6 4-(1-piperidino)aniline 
• 86-38-4 6,9-dichloro-2-methoxyacridine 

Relevant articles and documents

Solvent- and chromatography-free amination of π-deficient nitrogen heterocycles under microwave irradiation. A fast, efficient and green route to 9-aminoacridines, 4-aminoquinolines and 4-aminoquinazolines and its application to the synthesis of the drugs amsacrine and bistacrine

Focused microwave irradiation of equimolecular mixtures of 9-chloroacridines, 4-chloroquinolines and 4-chloroquinazolines with amines in the presence of 2 equiv of phenol allows the general, fast and high-yielding synthesis of aminated heterocycles, with a very broad scope in terms of amine structure (aromatic, linear primary aliphatic, α-branched primary aliphatic, secondary aliphatic and diamines). Workup consisted of a simple washing with water and purification could be achieved by crystallization, avoiding the use of organic solvents in extraction and chromatographic purification steps. This protocol provides a solution to the long-standing synthetic problem of achieving a practical and efficient method for the amination of π-deficient nitrogen heterocycles for medicinal chemistry applications.