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107028-33-1

107028-33-1

107028-33-1

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Synonyms:

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Chemical Properties

Safety information and MSDS view more

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  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 8 Articles be found

Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors

Si, Dongjuan,Luo, Huijuan,Zhang, Xiaomeng,Yang, Kundi,Wen, Hongmei,Li, Wei,Liu, Jian

, (2021/08/27)

Inhibition of the interactions of the tumor suppressor protein p53 with its negative regulators MDM2 in vitro and in vivo, representing a valuable therapeutic strategy for cancer treatment. The natural product chalcone exhibited moderate inhibitory activity against MDM2, thus based on the binding mode between chalcone and MDM2, a hit unsaturated pyrrolidone scaffold was obtained through virtual screening. Several unsaturated pyrrolidone derivatives were synthesized and biological evaluated. As a result, because the three critical hydrophobic pockets of MDM2 were occupied by the substituted-phenyl linked at the pyrrolidone fragment, compound 4 h demonstrated good binding affinity with the MDM2. Additionally, compound 4 h also showed excellent antitumor activity and selectivity, and no cytotoxicity against normal cells in vitro. The further antitumor mechanism studies were indicated that compound 4 h could successfully induce the activation of p53 and corresponding downstream p21 proteins, thus successfully causing HCT116 cell cycle arrest in the G1/M phase and apoptosis. Thus, the novel unsaturated pyrrolidone p53-MDM2 inhibitors could be developed as novel antitumor agents.

Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines

Ramajayam,Giridhar, Rajani,Yadav,Balaraman,Djaballah, Hakim,Shum, David,Radu, Constantin

, p. 2004 - 2010 (2008/12/22)

The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet properties may be mediated by interference with the arachidonic acid pathway.

An efficient and time saving microwave-assisted selenium dioxide oxidation of 1,2-diarylethanones

Shirude,Patel,Giridhar,Yadav

, p. 1080 - 1085 (2007/10/03)

Selenium dioxide oxidation of 1,2-diarylethanones to corresponding diones by conventional method takes upto 8 hr. The same oxidation under microwave radiations using dimethylsulfoxide as solvent reduces the reaction time considerably (30 to 90 sec). The method reported is efficient and time saving.

Process route upstream and downstream products

Process route

3-(4-bromo-phenyl)-2,4-bis-(4-chloro-phenyl)-3-hydroxy-butyric acid

3-(4-bromo-phenyl)-2,4-bis-(4-chloro-phenyl)-3-hydroxy-butyric acid

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone
107028-33-1

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

Conditions
Conditions Yield
With sodium hydroxide;
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

bromobenzene
108-86-1,52753-63-6

bromobenzene

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone
107028-33-1

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

Conditions
Conditions Yield
With aluminum (III) chloride; thionyl chloride; at 0 - 20 ℃; for 0.75h;
71.3%
4-chlorophenylacetic Acid; With phosphorus trichloride; for 1h; Heating / reflux;
bromobenzene; With aluminum (III) chloride; In carbon disulfide; for 3.5h; Heating / reflux;
With hydrogenchloride; water; In carbon disulfide; at 0 ℃; for 1h;
54%
bromobenzene
108-86-1,52753-63-6

bromobenzene

4-chlorophenacetyl chloride
25026-34-0

4-chlorophenacetyl chloride

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone
107028-33-1

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

Conditions
Conditions Yield
With aluminium trichloride;
55%
With aluminium trichloride;
With aluminium trichloride; at 20 ℃; for 0.75h;
With aluminium trichloride; at 20 ℃; for 0.75h;
With aluminum (III) chloride; at 0 - 20 ℃; for 8.5h;
4.59 g
3-(4-bromo-phenyl)-2-(4-chloro-phenyl)-3-oxo-propionaldehyde

3-(4-bromo-phenyl)-2-(4-chloro-phenyl)-3-oxo-propionaldehyde

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone
107028-33-1

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

Conditions
Conditions Yield
With ethylenediamine; In tetrahydrofuran; for 3h; Heating;
86%
1-(4-bromophenyl)-1-(4-chlorophenyl)ethene

1-(4-bromophenyl)-1-(4-chlorophenyl)ethene

2-(4-bromophenyl)-1-(4-chlorophenyl)ethan-1-one
23566-00-9

2-(4-bromophenyl)-1-(4-chlorophenyl)ethan-1-one

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone
107028-33-1

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

Conditions
Conditions Yield
With iodine tris(trifluoroacetate); In tetrachloromethane; at 23 ℃; for 3h; Yield given;
(4-bromophenyl)(3-(4-chlorophenyl)oxiran-2-yl)methanone
27547-11-1

(4-bromophenyl)(3-(4-chlorophenyl)oxiran-2-yl)methanone

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone
107028-33-1

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: boron trifluoride etherate / CH2Cl2 / 2 h / cooling
2: 86 percent / ethylene diamine / tetrahydrofuran / 3 h / Heating
With boron trifluoride diethyl etherate; ethylenediamine; In tetrahydrofuran; dichloromethane;
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone
107028-33-1

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: SOCl2 / 3 h / Heating
2: AlCl3 / 0.75 h / 20 °C
With aluminium trichloride; thionyl chloride; 2: Friedel-Crafts reaction;
Multi-step reaction with 2 steps
1: PCl3
2: 55 percent / anhydrous AlCl3
With aluminium trichloride; phosphorus trichloride; 2: Friedel-Crafts acylation;
Multi-step reaction with 2 steps
1: thionyl chloride / 7 h / 0 - 80 °C
2: aluminum (III) chloride / 8.5 h / 0 - 20 °C
With aluminum (III) chloride; thionyl chloride; 2: |Friedel-Crafts Acylation;
1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone
107028-33-1

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

ethane-1,2-dithiol
540-63-6

ethane-1,2-dithiol

2-(4-bromophenyl)-2-(4-chlorobenzyl)-1,3-dithiolane

2-(4-bromophenyl)-2-(4-chlorobenzyl)-1,3-dithiolane

Conditions
Conditions Yield
With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 96h;
100%
1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone
107028-33-1

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

C<sub>14</sub>H<sub>9</sub>Br<sub>2</sub>ClO

C14H9Br2ClO

Conditions
Conditions Yield
With bromine; In diethyl ether; at 20 ℃; for 2h; Inert atmosphere;
1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone
107028-33-1

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

4-methoxy-aniline
104-94-9

4-methoxy-aniline

N-(1-(4-bromophenyl)-2-(4-chlorophenyl)ethylidene)-4-methoxyaniline
1416727-99-5

N-(1-(4-bromophenyl)-2-(4-chlorophenyl)ethylidene)-4-methoxyaniline

Conditions
Conditions Yield
4-methoxy-aniline; With titanium tetrachloride; triethylamine; In dichloromethane; for 0.5h; Inert atmosphere; Cooling with ice;
1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone; In dichloromethane; at 20 - 40 ℃; for 5h; Inert atmosphere;

107028-33-1 Upstream products

107028-33-1 Downstream products

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