107512-35-6Relevant articles and documents
A pantoprazole intermediate 2 - chloromethyl - 3, 4 - dimethoxy pyridine hydrochloride preparation method
-
Paragraph 0030; 0031, (2018/09/08)
The invention belongs to the technical field of medicine, and particularly relates to a preparation method of a pantoprazole intermediate 2-chloromethyl-3,4-dimethoxy pyridine hydrochloride. The preparation method comprises the following steps: using 3-hydroxyl-2-methyl-4-pyrone as a starting raw material, and then only performing five-step reaction to obtain the pantoprazole intermediate 2-chloromethyl-3,4-dimethoxy pyridine hydrochloride. The preparation method reduces the reaction steps, shortens the reaction cycle, improves the working efficiency, and increases the yield coefficient.
New Synthesis of Orelline by Metalation of Methoxypyridines
Trecourt, Francois,Mallet, Marc,Mongin, Olivier,Gervais, Bruno,Queguiner, Guy
, p. 8373 - 8380 (2007/10/02)
A new total synthesis in five steps of alkaloid Orelline is reported.The methodology involves metalation of methoxypyridines to afford 2-halo-3,4-dimethoxypyridine on which an homocoupling reaction is performed to build the 2,2'-bipyridyl structure of the
Pyridine derivatives, and use as anti-ulcer agents
-
, (2008/06/13)
The compound of the formula STR1 wherein R1 is hydrogen, fluorine, methoxy or trifluoromethyl, R2 is a C1-8 alkyl, R3 is a C1-8 alkyl which may be fluorinated, and n is 0 or 1, or a pharmacologically acceptable salt thereof is useful for prevention and treatment of digestive ulcers (e.g. gastric ulcer, duodenal ulcer) and gastritis.