1075726-71-4

Basic information

• Product Name: (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-tert-butoxycarbonylethyl-isoquinoline oxalate
• Synonyms: (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-tert-butoxycarbonylethyl-isoquinoline oxalate
• CAS NO: 1075726-71-4
• Molecular Weight: 561.629
• Mol File: 1075726-71-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-tert-butoxycarbonylethyl-isoquinoline oxalate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-tert-butoxycarbonylethyl-isoquinoline oxalate(1075726-71-4)
• EPA Substance Registry System: (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-tert-butoxycarbonylethyl-isoquinoline oxalate(1075726-71-4)

Safety Data

• Hazardous Substances Data: 1075726-71-4(Hazardous Substances Data)

Usage

Uses

(R)-tert-Butyl-N-butanoate Norlaudanosine Oxalate is an intermediate in the synthesis of cisatracurium.

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 144-62-7 oxalic acid 
• 54417-53-7 (R)-tetrahydropapaverine hydrochloride 
• 141109-12-8 (R)-tetrahydropapaverine N-acetyl-L-leucine salt 

Downstream Products

• 1075726-83-8 (1R-cis)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-2-tert-butoxycarbonylethyl-isoquinolinium iodide 
• 1075727-02-4 (1R-trans)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-2-tert-butoxycarbonylethyl-isoquinolinium besylate 
• 1075727-00-2 (1R-cis)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-2-tert-butoxycarbonylethyl-isoquinolinium besylate 
• 64228-78-0 N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis-(R)-(-)-tetrahydropapaverine dioxalate 

Relevant articles and documents

Preparation method of cisatracurium besilate intermediate

The invention discloses a preparation method of a cisatracurium besilate intermediate. The method comprises the following steps: adding an alkali into a compound III for dissociation, reacting with tert-butyl acrylate under the catalysis of acetic acid, and adding oxalic acid for salifying to obtain a compound shown as formula VI; adding an alkali into the compound VI for dissociation; salifyingin the presence of excessive benzenesulfonic acid, then hydrolyzing tert-butyl ester in an obtained product into carboxylic acid under heating conditions to obtain a compound as shown in formula VII,then performing esterification reaction with 1, 5-pentanediol in situ to generate an esterification product, washing the excessive compound as shown in formula VII with water, adding an alkali for alkalization, and salifying with oxalic acid to obtain an intermediate as shown in formula IV. The obtained finished product is high in yield and high in purity, the finished product can be directly added into a last step of reaction of cisatracurium besilate without refining to finally prepare cisatracurium besilate, after-treatment is simple, and industrial production is easy.

PROCESS FOR PRODUCING CISATRACURIUM COMPOUNDS AND ASSOCIATED INTERMEDIATES

The present invention provides processes for producing isoquinolinium compounds, and for converting them into cisatracurium salts, e.g., cisatracurium besylate