107648-80-6

Basic information

• Product Name: Cefeprime dihydrochloride
• Synonyms: CEFEPIME DIHYDROCHLORIDE;CEFEPIME HCL;CEFEPIME HCL STERILE POWDER;CEFEPRIME DIHYDROCHLORIDE;(6R,7R)-7-[[(2E)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid chloride hydrochloride;PyrrolidiniuM,1-[[(6R,7R)-7-[[(2Z)-2-(2-aMino-4-thiazolyl)-2-(Me;CefepiMe hydrochloric;PyrrolidiniuM,1-[[(6R,7R)-7-[[(2Z)-2-(2-aMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]-1-Methyl-,chloride, hydrochloride (1:1:1
• CAS NO: 107648-80-6
• Molecular Formula: C19H25ClN6O5S2
• Molecular Weight: 553.49
• EINECS: 1592732-453-0
• Product Categories: Cefepime;Pharmaceutical intermediate
• Mol File: 107648-80-6.mol

Chemical Properties

• Melting Point: 230 °C (decomp)
• Appearance: /
• CAS DataBase Reference: Cefeprime dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Cefeprime dihydrochloride(107648-80-6)
• EPA Substance Registry System: Cefeprime dihydrochloride(107648-80-6)

Safety Data

• Hazardous Substances Data: 107648-80-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cefeprime dihydrochloride is used as an antibiotic for treating a wide range of bacterial infections due to its broad-spectrum activity and effectiveness against both gram-positive and gram-negative bacteria.
Used in Respiratory Infections Treatment:
Cefeprime dihydrochloride is used as a therapeutic agent for respiratory tract infections, helping to prevent the spread and worsening of the infection in the respiratory system.
Used in Urinary Tract Infections Treatment:
Cefeprime dihydrochloride is used as a treatment for urinary tract infections, targeting bacteria that cause inflammation and infection in the urinary system.
Used in Skin and Soft Tissue Infections Treatment:
Cefeprime dihydrochloride is used as an antimicrobial agent for skin and soft tissue infections, promoting healing and preventing further infection.
Used in General Bacterial Infections Treatment:
Cefeprime dihydrochloride is used as a broad-spectrum antibiotic for treating various types of bacterial infections in different organs and systems of the body, ensuring effective control and management of the infection.
Cefeprime dihydrochloride is typically administered orally or through intravenous injection, making it a convenient and well-tolerated treatment option for most patients with minimal side effects. Its versatility and efficacy in treating a wide range of bacterial infections make it an indispensable drug in the field of medicine.

Upstream product

• 959246-33-4 (benzothiazol-2-yl)-2-(2-aminothiazol-4-yl)-Z-2-methoxyimino-thioacetate 
• 113703-50-7 1-[((6R,7R)-7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-methylpyrrolidinium chloride hydrochloride 
• 111390-01-3 1-[((6R,7R)-7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-methylpyrrolidinium iodide 
• 103121-85-3 1-[((6R,7R)-7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-methylpyrrolidinium chloride 

Relevant articles and documents

PROCESS FOR THE DIRECT PREPARATION OF CEFEPIME FOR INJECTABLE USE

The present invention concerns a direct process, without the need to isolate any intermediate, for the preparation of Cefepime dihydrochloride monohydrate of sterile quality (for injective use) comprising a preliminary decolorization step in water of the compound of formula (II) in the presence of base or acid, an acylation step with MAEM in the presence of at least one solvent miscible in water, an extraction step in the presence of a solvent immiscible with water, a decolorization step of the rich water solution containing the dissolved product and, lastly, a crystallisation step of the product with acetone in the presence of hydrochloric acid.