107667-60-7

Basic information

• Product Name: Polaprezinc
• Synonyms: POLAPREZINC;zinc l-carnosine complex;zinc n-(3-aminopropionyl)histidine;ZINC CARNOSINE;[b-Alanyl-kN-L-histidinato(2-)-kN,kO]-zinc;b-Alanyl-L-histidinato Zinc;Promac;Z 103
• CAS NO: 107667-60-7
• Molecular Formula: C₉H₁₂N₄O₃*Zn
• Molecular Weight: 289.61
• EINECS: 1592732-453-0
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 107667-60-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 177.5°C
• Flash Point: 291oC
• Appearance: White to pale-yellow crystalline solid
• Storage Temp.: Refrigerator
• Solubility: Aqueous Acid (Slightly)
• CAS DataBase Reference: Polaprezinc(CAS DataBase Reference)
• NIST Chemistry Reference: Polaprezinc(107667-60-7)
• EPA Substance Registry System: Polaprezinc(107667-60-7)

Safety Data

• Hazardous Substances Data: 107667-60-7(Hazardous Substances Data)

Usage

Description

Polaprezinc, a complex of zinc ion and L-carnosine, is an antiulcer agent launched in Japan. It is effective in promoting the healing of gastric ulcers in addition to preventing ulcer relapse. In rat studies, polaprezinc reduces the incidence of stomach lesions induced by ethanol. No effect was seen on ultrastructural damage or on cell proliferation and it appears that polaprezinc combines the cytoprotective effect of zinc with the ulcer healing properties of Lcarnosine. The in vivo antioxidative properties of polaprezinc has been suggested to be responsible for its protective effect against gastric mucosal injury. Recent studies revealed that polaprezinc is an activator of bone formetion and has inhibitory effect of bone resorption. This agent is thus able to prevent the deterioration of bone metabolism indicating its potential usefulness in the treatment of osteoporosis. Polaprezinc has also been claimed for the prophylaxis and treatment of alcoholic hepatopathy, viral hepatitis or other hepatopathies caused by certain drugs, poisons and radiation.

Chemical Properties

White To Pale-Yellow Crystalline Solid

Originator

Hamari Chemicals (Japan)

Uses

Different sources of media describe the Uses of 107667-60-7 differently. You can refer to the following data:
1. A novel anti-gastric ulcer agent
2. PepZinGI(R) is a new dietary supplement approved by the federal agency. Don`t hesitate to contact us for more information. Attributes New dietary supplement Contact
3. anti-ulcer drug, antioxidative,

Brand name

Promac

InChI:InChI=1/C9H14N4O3.Zn/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6;/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16);/q;+2

Upstream product

• 5970-45-6 zinc(II) acetate dihydrate 
• 305-84-0 carnosine 
• 1535206-09-7 Zn(β-alanyl-L-histidine)*DMF 

Relevant articles and documents

Methods for producing L-carnosine zinc complex

Disclosed is a method for conveniently synthesizing, at high purity and high yield, a crystalline L-carnosine zinc complex which is useful as an antiulcer treatment agent without having a separate refining step. A method for producing an L-carnosine zinc complex comprises the steps of: suspending L-carnosine and zinc salts in an alcohol or a water-containing alcohol; producing an alkali metal compound solution by dissolving an alkali metal compound in an alcohol or a water-containing alcohol; precipitating an L-carnosine zinc complex by adding the alkali metal compound solution in a suspension of the L-carnosine and the zinc salts; adding refined water in a reactive liquid including the L-carnosine zinc complex; and filtering an L-carnosine zinc complex crystal.COPYRIGHT KIPO 2017