108512-13-6

Basic information

• Product Name: 1,4-DIACETYL-2-METHYLIMIDAZOLE
• Synonyms: 1,4-DIACETYL-2-METHYLIMIDAZOLE
• CAS NO: 108512-13-6
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.1772
• Mol File: 108512-13-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 325.1°C at 760 mmHg
• Flash Point: 150.4°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.000235mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 1,4-DIACETYL-2-METHYLIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIACETYL-2-METHYLIMIDAZOLE(108512-13-6)
• EPA Substance Registry System: 1,4-DIACETYL-2-METHYLIMIDAZOLE(108512-13-6)

Safety Data

• Hazardous Substances Data: 108512-13-6(Hazardous Substances Data)

Usage

Type of compound

Organic compound

Applications

a. Production of pharmaceuticals
b. Research chemical
c. Reagent in organic synthesis
d. Component in the synthesis of various organic compounds

Physical appearance

White to off-white crystalline solid

Solubility

Soluble in organic solvents

Stability

Relatively stable compound

Storage and handling

Can be stored and handled without special precautions, but should be handled with care

Potential hazards

a. Potential irritant
b. Harmful if ingested or inhaled

InChI:InChI=1/C8H10N2O2/c1-5(11)8-4-10(7(3)12)6(2)9-8/h4H,1-3H3

Upstream product

• 100499-65-8 3-acetamido-4-amino-3-buten-2-one 
• 100499-63-6 N-(5-methyl-4-isoxazolyl)acetamide 
• 78210-66-9 4⁽⁵⁾-acetyl-2-methyl-1H-imidazole 
• 75-36-5 acetyl chloride 

Downstream Products

• 103747-88-2 5-acetyl-1,2-dimethylimidazole 

Relevant articles and documents

Synthesis of 4(5)-Acyl-, 1-Substituted 5-Acyl, and 1-Substituted 4-Acyl-1H-imidazoles from 4-Aminoisoxazoles

4-Aminoisoxazoles can be acylated with a wide variety of activated carboxylic acids.Hydrogenation of the resulting amides gives α-(acylamino)enaminones, which cyclize to 4(5)-acylimidazoles upon treatment with base.This method allows for the synthesis of acylimidazoles with a wide range of substituents at C-2.Utilization of N-substituted 4-aminoisoxazoles in the same sequence of reactions yields 1-substituted 5-acylimidazoles, a substitution pattern not otherwise easily prepared.Treatment of α-(acylamino)enaminones, derived from N-unsubstituted isoxazoles, with primary amines leads to incorporation of the amine at the β-position with concomitant expulsion of ammonia.This sequence efficiently yields 1-substituted and 1,2-disubstituted 4-acylimidazoles but does not give satisfactory yields of 5-substituted 4-acylimidazoles due to steric inhibition of the amine exchange.