1089279-66-2

Basic information

• Product Name: tert-butyl 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine-1-carboxylate
• CAS NO: 1089279-66-2
• Molecular Weight: 420.509
• Mol File: 1089279-66-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine-1-carboxylate(1089279-66-2)
• EPA Substance Registry System: tert-butyl 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine-1-carboxylate(1089279-66-2)

Safety Data

• Hazardous Substances Data: 1089279-66-2(Hazardous Substances Data)

Upstream product

• 41979-39-9 4-piperidone hydrochloride 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 205059-24-1 tert-butyl 4-(piperidin-4-yl)piperazine-1-carboxylate 
• 761440-64-6 1-(3-methoxy-4 nitrophenyl)piperidin-4-one 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 1089279-61-7 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine 

Relevant articles and documents

PROTEIN DEGRADATION TARGETING COMPOUND, ANTI-TUMOR APPLICATION, INTERMEDIATE THEREOF AND USE OF INTERMEDIATE

The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

ALK (anaplastic lymphoma kinase) protein degradation agent and anti-tumor application thereof

The invention discloses a compound in a formula (I) and an anti-tumor application thereof. The compound in the formula (I) has degradation and inhabitation functions on ALK target protein and mainly comprises four parts, the first part ALK-TKIs is a compound with ALK tyrosine kinase inhabitation activity; the second part LIN is different linkers; the third part ULM (ubiquitin ligase binding moiety) of VHL, CRBN or other protease micromolecular ligand with a ubiquitination function; the fourth part group A is carboxyl or deficiency and covalently binds ALK-TKIs with LIN and covalently binds LINwith ULM. A series of designed and synthesized compounds have wide pharmacological activity, have functions of degrading ALK protein and inhibiting ALK activity and can be applied to related tumor therapy.

Diaminopyrimidine compound and composition containing same

The invention provides a diaminopyrimidine compound and a composition containing the same and discloses the diaminopyrimidine compound shown as in a formula (I) and a drug combination containing the compound or salt thereof acceptable in crystal form and