1089279-90-2

Basic information

• Product Name: 1-(5-Methoxy-2-Methyl-4-nitrophenyl)-N,N-diMethylpiperidin-4-aMine
• Synonyms: 1-(5-Methoxy-2-Methyl-4-nitrophenyl)-N,N-diMethylpiperidin-4-aMine;1-(3-methoxy-4-nitrophenyl)-N,N-dimethylpiperidin-4-amine
• CAS NO: 1089279-90-2
• Molecular Formula: C₁₄H₂₁N₃O₃
• Molecular Weight: 293.36142
• Mol File: 1089279-90-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 437.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 9.14±0.20(Predicted)
• CAS DataBase Reference: 1-(5-Methoxy-2-Methyl-4-nitrophenyl)-N,N-diMethylpiperidin-4-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Methoxy-2-Methyl-4-nitrophenyl)-N,N-diMethylpiperidin-4-aMine(1089279-90-2)
• EPA Substance Registry System: 1-(5-Methoxy-2-Methyl-4-nitrophenyl)-N,N-diMethylpiperidin-4-aMine(1089279-90-2)

Safety Data

• Hazardous Substances Data: 1089279-90-2(Hazardous Substances Data)

Usage

General Description

1-(5-Methoxy-2-Methyl-4-nitrophenyl)-N,N-diMethylpiperidin-4-aMine, also known as 4-MMC or mephedrone, is a synthetic stimulant drug that belongs to the amphetamine and cathinone classes. It is structurally related to methcathinone, which is a psychoactive drug found in the khat plant. Mephedrone is known for its psychoactive effects and has been linked to increased energy, euphoria, and heightened sensory perception. It has gained popularity as a recreational drug and is often used in settings such as parties and clubs. However, it is also associated with potential health risks and has been a topic of legal and regulatory concern in various jurisdictions due to its potential for misuse and addiction.

Upstream product

• 446-36-6 5-fluoro-2-nitrophenol 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 172281-90-2 N,N-dimethylpiperidine-4-amine hydrochloride 
• 41979-39-9 4-piperidone hydrochloride 
• 761440-22-6 1-(3-methoxy-4-nitrophenyl)piperidin-4-ol 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 50533-97-6 dimethyl-piperidin-4-yl-amine 
• 761440-64-6 1-(3-methoxy-4 nitrophenyl)piperidin-4-one 
• 124-40-3 dimethyl amine 

Downstream Products

• 1197958-12-5 (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl )amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide 
• 1089279-91-3 1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidine-4-amine 

Relevant articles and documents

Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing a sulfoxide moiety as anaplastic lymphoma kinase (ALK) inhibition agents

Anaplastic lymphoma kinase (ALK) targeted therapies have demonstrated remarkable efficacy in ALK-positive lung adenocarcinomas. Here we synthesized and evaluated sixteen new 2,4-diaminopyrimidines bearing a sulfoxide moiety as anaplastic lymphoma kinase (ALK) inhibitors. The optimal compound 9e exhibited excellent antiproliferative activity against non-small cell lung cancer NCI-H2228 cells, which is better than that of Brigatinib and similar to Ceritinib. Mechanism study revealed that the optimal compound 9e decreased the mitochondrial membrane potential and arrested NCI-H2228 cells in the G0/G1 phase, finally resulting in cellular apoptosis. It is interesting that 9e could effectively inhibit the migration of NCI-H2228 cells and may be a promising leading compound for chemotherapy of metastatic cancer.

PYRIMIDINE DERIVATIVE AND USE THEREOF

The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.

NOVEL CHEMICAL COMPOUNDS (VARIANTS) AND THE USE THEREOF TO TREAT ONCOLOGICAL DISEASES

The invention relates to novel chemical compounds of general formula I, in which L A , L B , L C , ring A, ring B, R A , R B , R C ,R D ,R E and R F have are defined in the description, and which are protein kinases inhibitors. The invention also relates