F:Highly flammable;
109-74-0Relevant articles and documents
Microwave-assisted efficient one-pot synthesis of nitriles from aldehydes in the presence of P2O5/SiO2 in solvent-free media
Eshghi, Hossein,Gordi, Zinat
, p. 619 - 623 (2005)
A rapid and efficient procedure is developed for a one-pot synthesis of nitrites by condensation of aldehydes with hydroxylamine hydrochloride in the presence of P2O5/SiO2 in solvent-free media under microwave irradiation. Copyright Taylor & Francis Inc.
Reaction of interstitial cyanide ions in a hydrotalcite-like material with organic chlorides
Suzuki, Eiichi,Inoue, Atsushi,Ono, Yoshio
, p. 1291 - 1292 (1998)
A hydrotalcite-like material, Mg6Al2(OH)16Cl2-xCN x·4H2O (x= 1.53-1.94), was prepared and tested as a reagent for the nucleophilic substitution for chlorine atom of C6H5CH2Cl, C4H9Cl, and C3H7Cl by the CN ions in the interlayer of the material. The corresponding organic cyanides were obtained at 353 K in a non-polar solvent, toluene.
Rhodium-Catalysed Asymmetric Hydroformylation of Unsaturated Nitriles
Lambers-Verstappen, Marielle M.H.,De Vries, Johannes G.
, p. 478 - 482 (2003)
Asymmetric hydroformylation of crotononitrile (1) and ally cyanide (2) was probed with the view to develop a synthesis for (R)-4-amino-2-methyl-butan-1-ol. Hydroformylation of 1 under a variety of conditions mainly led to hydrogenated product. Hydroformylation of 2 with Rh/tris(2,4-di-tert-butylphenyl) phosphite gave good selectivity to the formylated nitrile with an n/iso of 77:23. Asymmetric hydroformylation of 2 could be accomplished in 66% ee using Rh/(R,S)-BINAPHOS.
Purification and characterization of aldoxime dehydratase of the head blight fungus, Fusarium graminearum
Kato, Yasuo,Asano, Yasuhisa
, p. 2254 - 2257 (2005)
Fungal aldoxime dehydratase (Oxd) of Fusarium graminearum MAFF305135 was purified and characterized for the first time from its overexpressing Escherichia coli transformant. The enzyme showed about 20% identity with known Oxds, and had similar enzymatic properties with nitrilase-linked Oxd from the Bacillus strain. It belongs to a group of phenylacetaldoxime dehydratases (EC 4.99.1.7), based on its substrate specificity and kinetic analysis.
Thermal Desorption and Infrared Studies of Primary Aliphatic Amines adsorbed on Haematite (α-Fe2O3)
Marx, Ute,Sokoll, Rolf,Hobert, Hartmut
, p. 2505 - 2514 (1986)
The adsorption of n-octadecylamine on α-Fe2O3 at the solid/liquid interface, and of n-butylamine at the solid/liquid and solid/vapour interfaces has been studied by infrared spectroscopy.To obtain further information about the nature of desorbing products, temperature-programmed desorption experiments were made with n-butylamine-α-Fe2O3 adsorbates.No difference could be detected by i.r. spectroscopy between the nature of adsorbates formed under the various mentioned conditions.Adsorption of n-octadecylamine and n-butylamine on α-Fe2O3 mainly involves coordinative interactions between amine and Lewis-acidic surface sites (Fe(3+) cations).Furthermore, hydrogen bonds are formed between surface hydroxy groups and adsorbed amine molecules. n-Butylamine adsorbed on α-Fe2O3 gave four different desorption peaks (I-IV) which are formed by n-butylamine (I:423 K), butyronitrile (II:530 K), CO2 (III:630K) and H2O (IV:713 K).Desorption of CO2 and H2O is caused by the oxidation of amine molecules strongly adsorbed on two different types of coordination sites.
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Lewis,Susi
, p. 840 (1952)
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Facile dehydration of primary amides to nitriles catalyzed by lead salts: The anionic ligand matters
Ruan, Shixiang,Ruan, Jiancheng,Chen, Xinzhi,Zhou, Shaodong
, (2020/12/09)
The synthesis of nitrile under mild conditions was achieved via dehydration of primary amide using lead salts as catalyst. The reaction processes were intensified by not only adding surfactant but also continuously removing the only by-product, water from the system. Both aliphatic and aromatic nitriles can be prepared in this manner with moderate to excellent yields. The reaction mechanisms were obtained with high-level quantum chemical calculations, and the crucial role the anionic ligand plays in the transformations were revealed.
Enantioselective Radical Carbocyanation of 1,3-Dienes via Photocatalytic Generation of Allylcopper Complexes
Lu, Fu-Dong,Lu, Liang-Qiu,He, Gui-Feng,Bai, Jun-Chuan,Xiao, Wen-Jing
supporting information, p. 4168 - 4173 (2021/04/06)
1,3-Dienes are readily available feedstocks that are widely used in the laboratory and industry. However, the potential of converting 1,3-dienes into value-Added products, especially chiral products, has not yet been fully exploited. By synergetic photoredox/copper catalysis, we achieve the first visible-light-induced, enantioselective carbocyanation of 1,3-dienes by using carboxylic acid derivatives and trimethylsilyl cyanide. Under mild and neutral conditions, a diverse range of chiral allyl cyanides are produced in generally good efficiency and with high enantioselectivity from bench-stable and user-safe chemicals. Moreover, preliminary results also confirm that this success can be expanded to 1,3-enynes and the four-component carbonylative carbocyanation of 1,3-dienes and 1,3-enynes.
Method for continuous preparation of nitriles by amides (by machine translation)
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Paragraph 0033-0054; 0061-0066, (2020/12/15)
The method comprises the following steps: preparing a lead salt supported by a molecular sieve by a lead salt and a molecular sieve through an impregnation method; and filling a molecular sieve-loaded lead catalyst into a fixed bed reactor. The amide or amide solution is sent into a fixed bed reactor from the top of the fixed bed to be subjected to catalytic dehydration, and the obtained reaction product is led out from the bottom of the fixed bed. The reaction product is separated to obtain the crude product of the nitrile corresponding to the amide. A fixed bed continuous production process is adopted, the reaction process is simple, the production efficiency is high, the product post-treatment is simple, and industrial production is easy to realize. (by machine translation)
