Welcome to LookChem.com Sign In|Join Free

CAS

  • or

109-78-4

Post Buying Request

109-78-4 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

109-78-4 Usage

General Description

3-Hydroxypropanenitrile, also known as beta-hydroxypropionitrile, is a chemical compound with the molecular formula C3H5NO. It is an organic compound that contains a hydroxyl group and a nitrile group. 3-Hydroxypropanenitrile is a colorless liquid with a pungent odor and is soluble in water. It is primarily used in the production of chemicals and pharmaceuticals, and as a precursor for the synthesis of various organic compounds. It is also commonly used as a building block in the synthesis of polymers and other complex molecules. Additionally, 3-Hydroxypropanenitrile has been studied for its potential use in the development of new drugs and pharmaceuticals due to its unique chemical properties.

Check Digit Verification of cas no

The CAS Registry Mumber 109-78-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 109-78:
(5*1)+(4*0)+(3*9)+(2*7)+(1*8)=54
54 % 10 = 4
So 109-78-4 is a valid CAS Registry Number.
InChI:InChI=1/C3H5NO/c4-2-1-3-5/h5H,1,3H2

109-78-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Hydroxypropionitrile

1.2 Other means of identification

Product number -
Other names Ethylene Cyanohydrin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:109-78-4 SDS

109-78-4Synthetic route

acrylonitrile
107-13-1

acrylonitrile

A

3,3'-thiobis-propanenitrile
111-97-7

3,3'-thiobis-propanenitrile

B

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With sodium sulfide; benzyltri(n-butyl)ammonium chloride In water for 0.166667h;A 98%
B n/a
oxirane
75-21-8

oxirane

hydrogen cyanide
74-90-8

hydrogen cyanide

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With aluminum oxide; boron trifluoride diethyl etherate In propylene glycol at -10 - 10℃; for 28h; Reagent/catalyst; Temperature;97.3%
sodium cyanide
143-33-9

sodium cyanide

2-chloro-ethanol
107-07-3

2-chloro-ethanol

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With PEG400 for 6h; Heating;93%
acrylonitrile
107-13-1

acrylonitrile

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With sodium hydroxide at 50℃; for 0.2h;92%
With sodium hydroxide In water at 50℃; for 4h;65%
With water; copper(II) oxide
3-((tetrahydro-2H-pyran-2-yl)oxy)propanenitrile
90087-76-6, 89923-32-0

3-((tetrahydro-2H-pyran-2-yl)oxy)propanenitrile

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With silica-supported NaHSO4 In methanol at 20℃; for 0.25h;92%
With zinc(II) trifluoromethanesulfonate In methanol at 20℃; for 0.666667h;81%
3-(4-methoxybenzyloxy)propanenitrile

3-(4-methoxybenzyloxy)propanenitrile

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium nitrite at 20℃; for 18h; Green chemistry; chemoselective reaction;84%
potassium cyanide
151-50-8

potassium cyanide

2-chloro-ethanol
107-07-3

2-chloro-ethanol

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With sodium iodide In ethanol for 5h; Heating;80%
at 100℃;
With ethanol
3-(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)propanenitrile
131379-56-1

3-(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)propanenitrile

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With 2,3-dimethyl-1,4-benzoquinone; tetrabutyl ammonium fluoride; oxygen In tetrahydrofuran for 0.833333h; Ambient temperature;71%
acrylonitrile
107-13-1

acrylonitrile

phenol
108-95-2

phenol

A

3-phenoxypropionitrile
3055-86-5

3-phenoxypropionitrile

B

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With tetramethyl ammoniumhydroxide In water at 60℃; for 0.5h; Temperature; Reagent/catalyst; Time; Michael Addition; Microwave irradiation;A 68%
B n/a
aminocyclopropane-1-carboxylic acid
22059-21-8

aminocyclopropane-1-carboxylic acid

A

ethene
74-85-1

ethene

B

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With lithium hypochlorite In water Ambient temperature;A 9.8%
B 60%
With lithium hypochlorite In water Product distribution; Mechanism; Ambient temperature; other solvent and additives; var. cyclopropanamines;A 9.8%
B 60%
methyl 2-cyanoacetate
105-34-0

methyl 2-cyanoacetate

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With lithium aluminium hydride on silica gel In diethyl ether for 3h; Heating;54%
bromopropionitrile
2417-90-5

bromopropionitrile

A

acetic acid
64-19-7

acetic acid

B

acrylonitrile
107-13-1

acrylonitrile

C

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With oxygen; tetraethylammonium perchlorate In N,N-dimethyl-formamide at 20℃; electroreduction at -1.1 V;A 40 % Chromat.
B 10 % Chromat.
C 36%
Cyclopropylamine
765-30-0

Cyclopropylamine

A

ethene
74-85-1

ethene

B

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With lithium hypochlorite In water Ambient temperature;A 15%
B 30 mg
1-bromo-3-propanol
627-18-9

1-bromo-3-propanol

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
(i) NaN3, H2O, (ii) Pd, 2,5-dimethyl-hex-3-yne-2,5-diol, benzene; Multistep reaction;
methyl 1-aminocyclopropane-1-carboxylate
72784-43-1

methyl 1-aminocyclopropane-1-carboxylate

A

ethene
74-85-1

ethene

B

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With lithium hypochlorite In water at 5 - 10℃; for 0.333333h;
acrylonitrile
107-13-1

acrylonitrile

A

2-propenamide
79-06-1

2-propenamide

B

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With sodium hydroxide; Pt(Ppy3)4; water at 80℃; for 1h; Product distribution; var. platinum(0) catalysts;
at 70℃; for 8h; Product distribution; The selective hydration with several metal oxide catalysts.;
manganese(IV) oxide at 70℃; for 8h; Yield given;
acrylonitrile
107-13-1

acrylonitrile

A

2-cyanoethyl ether
1656-48-0

2-cyanoethyl ether

B

2-propenamide
79-06-1

2-propenamide

C

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
trans- at 80℃; Mechanism; Rate constant; Product distribution; in the absence or in the presence of different quantity of water;
trans- at 25℃; Rate constant; Product distribution; also in the presence of different quantity of acetamide;
sodium hydroxide In water at 80℃; Product distribution;
ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol for 16h;
N-nitro-β-aminopropionitrile
62984-38-7

N-nitro-β-aminopropionitrile

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
With sulfuric acid at 25 - 85℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), -ΔS(excit.);
furfural
98-01-1

furfural

water
7732-18-5

water

N-benzyl-trimethylammonium hydroxide
100-85-6

N-benzyl-trimethylammonium hydroxide

acrylonitrile
107-13-1

acrylonitrile

A

bis-(2-cyano-3ξ-[2]furyl-allyl)-ether
101291-29-6

bis-(2-cyano-3ξ-[2]furyl-allyl)-ether

B

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

C

3t-<2>furyl-2-hydroxymethyl-acrylonitrile

3t-<2>furyl-2-hydroxymethyl-acrylonitrile

D

3c-<2>furyl-2-hydroxymethyl-acrylonitrile and 2-<(2-cyano-ethoxy-methyl>-3-<2>furyl-acrylonitrile

3c-<2>furyl-2-hydroxymethyl-acrylonitrile and 2-<(2-cyano-ethoxy-methyl>-3-<2>furyl-acrylonitrile

2-chloro-ethanol
107-07-3

2-chloro-ethanol

alkali cyanide

alkali cyanide

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

2-bromoethanol
540-51-2

2-bromoethanol

alkali cyanide

alkali cyanide

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

oxirane
75-21-8

oxirane

salts of/the/ hydrocyanic acid

salts of/the/ hydrocyanic acid

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

acrylonitrile
107-13-1

acrylonitrile

aqueous NaOH-solution

aqueous NaOH-solution

A

2-propenamide
79-06-1

2-propenamide

B

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
at 20℃; Kinetics;
at 40℃; Kinetics;
acrylonitrile
107-13-1

acrylonitrile

A

2-cyanoethyl ether
1656-48-0

2-cyanoethyl ether

B

2-propenamide
79-06-1

2-propenamide

C

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

D

ethylene cyanohydrine, bis(2-cyanoethyl) ether

ethylene cyanohydrine, bis(2-cyanoethyl) ether

Conditions
ConditionsYield
With water; Ni(b),Cu(35) (X%) at 75℃; for 6h; Product distribution; Thermodynamic data; other time and catalyst composition; ΔE(excit); effect on the rate and product distribution;
oxirane
75-21-8

oxirane

hydrogen cyanide
74-90-8

hydrogen cyanide

water
7732-18-5

water

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Conditions
ConditionsYield
Reaktion von Calciumcyanid;
Reaktion von Calciumcyanid;
oxirane
75-21-8

oxirane

hydrogen cyanide
74-90-8

hydrogen cyanide

sodium cyanide
143-33-9

sodium cyanide

water
7732-18-5

water

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

oxirane
75-21-8

oxirane

hydrogen cyanide
74-90-8

hydrogen cyanide

water
7732-18-5

water

calcium cyanide

calcium cyanide

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

3-hydroxypropanimidamide hydrochloride
53868-56-7

3-hydroxypropanimidamide hydrochloride

Conditions
ConditionsYield
Stage #1: 3-Hydroxypropionitrile With acetyl chloride In methanol; toluene at 0 - 20℃; for 18h;
Stage #2: With ammonia In methanol at 0 - 20℃; for 18h;
100%
With hydrogenchloride; methanol; diethyl ether Umsetzen des Reaktionsprodukts mit NH3 in Metahnol bei 0grad;
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite
162611-40-7, 162611-41-8, 171081-08-6

5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite

O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite
171081-12-2

O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite

Conditions
ConditionsYield
With 1H-tetrazole In acetonitrile for 0.166667h; Ambient temperature;100%
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

O-(5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl-2-deoxyadenosin-3'-yl) N,N-diisopropylfluorophosphoramidite
162611-38-3, 162611-39-4, 171081-09-7

O-(5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl-2-deoxyadenosin-3'-yl) N,N-diisopropylfluorophosphoramidite

Phosphorofluoridous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
171081-13-3

Phosphorofluoridous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Conditions
ConditionsYield
With 1H-tetrazole In acetonitrile for 0.166667h; Ambient temperature;100%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

β-cyanoethyl chlorocarbonate
30436-27-2

β-cyanoethyl chlorocarbonate

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; 3-Hydroxypropionitrile In tetrahydrofuran at 0 - 20℃;
Stage #2: With pyridine In tetrahydrofuran at 0 - 20℃;
100%
In pyridine; toluene at 0℃;
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

3-((tert-butyldimethylsilyl)oxy)propanenitrile
89923-33-1

3-((tert-butyldimethylsilyl)oxy)propanenitrile

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 30℃;100%
With 1H-imidazole In tetrahydrofuran at 40℃; for 15h; Condensation;98%
With 1H-imidazole In dichloromethane at 20℃;94%
triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

3-triisopropylsilyloxypropionitrile

3-triisopropylsilyloxypropionitrile

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;100%
isocyanate de chlorosulfonyle
1189-71-5

isocyanate de chlorosulfonyle

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

C4H5ClN2O4S

C4H5ClN2O4S

Conditions
ConditionsYield
In dichloromethane for 1h;100%
(1'S)-1-(1'-phenylethyl)-3,4-epoxypyrrolidine
474755-59-4

(1'S)-1-(1'-phenylethyl)-3,4-epoxypyrrolidine

tert-butyl methyl ether
1634-04-4

tert-butyl methyl ether

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

(1'S)-1-(1'-phenylethyl)-3-hydroxy-4-methoxy-pyrrolidine

(1'S)-1-(1'-phenylethyl)-3-hydroxy-4-methoxy-pyrrolidine

Conditions
ConditionsYield
With sodium methylate In methanol; water100%
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

D-Ribono-1,4-lactone
5336-08-3

D-Ribono-1,4-lactone

C8H14N2O5
1254077-05-8

C8H14N2O5

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 1h;100%
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

3-hydroxypropanimidamide hydrochloric acid salt

3-hydroxypropanimidamide hydrochloric acid salt

Conditions
ConditionsYield
Stage #1: 3-Hydroxypropionitrile With acetyl chloride In methanol; toluene at 0 - 20℃; for 18h;
Stage #2: With ammonia In tetrahydrofuran; methanol at 0 - 20℃; for 18h;
100%
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

1-<3-(N-tert-butoxycarbonylamino)propyl>-4-phenylpiperidine-4-carboxylic acid
219553-44-3

1-<3-(N-tert-butoxycarbonylamino)propyl>-4-phenylpiperidine-4-carboxylic acid

1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine
219553-50-1

1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine

Conditions
ConditionsYield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane for 16h; Heating;99%
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

4-Phenylbutyric acid
1821-12-1

4-Phenylbutyric acid

2-cyanoethyl 4-phenylbutyrate

2-cyanoethyl 4-phenylbutyrate

Conditions
ConditionsYield
With Iron(III) isopropoxide; zirconium(IV) tetraisopropoxide In n-heptane for 23h;99%
tetrachlorobis(tetrahydrofuran)hafnium(IV) In toluene for 24h; Heating;94%
zirconium(IV) oxychloride In n-heptane for 5h; Heating;
3'-deoxy-3'-C-[(hydroxyphosphinyl)methyl]-5'-O-(4-methoxytrityl)-2'-O-methyl-4-N-(N-methylpyrrolidin-2-ylidene)-5-methylcytidine triethylamine salt

3'-deoxy-3'-C-[(hydroxyphosphinyl)methyl]-5'-O-(4-methoxytrityl)-2'-O-methyl-4-N-(N-methylpyrrolidin-2-ylidene)-5-methylcytidine triethylamine salt

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

3'-deoxy-3'-C-[[(2-cyanoethoxy)phosphinyl]methyl]-5'-O-(4-methoxytrityl)-2'-O-methyl-4-N-(N-methylpyrrolidin-2-ylidene)-5-methylcytidine

3'-deoxy-3'-C-[[(2-cyanoethoxy)phosphinyl]methyl]-5'-O-(4-methoxytrityl)-2'-O-methyl-4-N-(N-methylpyrrolidin-2-ylidene)-5-methylcytidine

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 65℃;99%
5-methyl-1,2,3-thiadiazolyl-4-carboxylic acid
22097-10-5

5-methyl-1,2,3-thiadiazolyl-4-carboxylic acid

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

2-cyanoethyl 5-methyl-1,2,3-thiadiazole-4-carboxylate

2-cyanoethyl 5-methyl-1,2,3-thiadiazole-4-carboxylate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In 1,2-dichloro-ethane at 0 - 20℃; for 3.5h; Inert atmosphere;99%
Cinnamoyl chloride
102-92-1

Cinnamoyl chloride

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

2-cyano-ethyl cinnamate
1426540-82-0

2-cyano-ethyl cinnamate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0℃; for 12h; Inert atmosphere;99%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

3-trimethylsilanyloxypropionitrile
42202-44-8

3-trimethylsilanyloxypropionitrile

Conditions
ConditionsYield
With triethylamine In diethyl ether at 0 - 23℃; for 16.3333h;98%
Stage #1: 3-Hydroxypropionitrile With triethylamine at 0℃;
Stage #2: chloro-trimethyl-silane In diethyl ether at 0℃; for 0.583333h;
98.5%
With triethylamine In diethyl ether at 0 - 23℃; for 16h; Inert atmosphere; Schlenk technique;98%
2,2,6-trimethyl-4H-1,3-dioxin-4-one
5394-63-8

2,2,6-trimethyl-4H-1,3-dioxin-4-one

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

2-cyanoethylacetoacetate
65193-87-5

2-cyanoethylacetoacetate

Conditions
ConditionsYield
In o-xylene at 141℃; for 2h;98.3%
In 5,5-dimethyl-1,3-cyclohexadiene at 140 - 145℃; for 1h;90%
In xylene at 140 - 145℃; for 1h;81.6%
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

3-hydroxypropionamide
2651-43-6

3-hydroxypropionamide

Conditions
ConditionsYield
With manganese(IV) oxide; water In isopropyl alcohol at 100℃; under 5171.62 Torr; for 0.833333h;98%
With CF3O3S(1-)*C36H35ClFeOP3Pt(1+); water; silver trifluoromethanesulfonate In tetrahydrofuran at 40℃; for 12h; Catalytic behavior; Inert atmosphere;92%
With silver tetrafluoroborate; C36H35ClFeOP3Pt(1+)*BF4(1-) In tetrahydrofuran; water at 80℃; for 12h;92%
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

Conditions
ConditionsYield
With ammonium hydroxide; hydrogen; silver nitrate In methanol at 45 - 75℃; under 1500.15 Torr; Temperature; High pressure; Inert atmosphere; Autoclave;98%
With hydrogen; nickel In isopropyl alcohol at 60℃; under 3102.9 Torr; 20-24 h;88%
With ammonium hydroxide; hydrogen at 80℃; under 60006 Torr; for 6h; Sealed tube;80%
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

2-chlorophenyl dichlorophosphate
15074-54-1

2-chlorophenyl dichlorophosphate

2-chlorophenyl bis<2-cyanoethyl>phosphate
96404-97-6

2-chlorophenyl bis<2-cyanoethyl>phosphate

Conditions
ConditionsYield
With pyridine In 1,4-dioxane for 4.5h; Ambient temperature;98%
2-(carboxymethyl)-5-nitrobenzoic acid
3898-66-6

2-(carboxymethyl)-5-nitrobenzoic acid

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

2-(2-cyano-ethoxycarbonylmethyl)-5-nitro-benzoic acid
623172-50-9

2-(2-cyano-ethoxycarbonylmethyl)-5-nitro-benzoic acid

Conditions
ConditionsYield
With sulfuric acid at 70℃; for 0.116667h;98%
1-benzyloxycarbonylpiperidine-4-carboxylic acid
10314-98-4

1-benzyloxycarbonylpiperidine-4-carboxylic acid

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

2-cyanoethyl (1-benzyloxycarbonyl-4-piperidine)carboxylate

2-cyanoethyl (1-benzyloxycarbonyl-4-piperidine)carboxylate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 5h; Ambient temperature;97%
1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

3-trimethylsilanyloxypropionitrile
42202-44-8

3-trimethylsilanyloxypropionitrile

Conditions
ConditionsYield
With ammonium thiocyanate In dichloromethane at 0℃; for 0.166667h;97%
at 135℃; for 2h;167 g
toluene-4-sulfonic acid at 100℃; for 2.5h;
toluene-4-sulfonic acid at 60 - 80℃; for 2.5 - 4.5h;
BOC-glycine
4530-20-5

BOC-glycine

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Boc-Gly-OCet
119866-74-9

Boc-Gly-OCet

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0℃; for 2h;97%
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide Ambient temperature;88%
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

O-(2-thiono-1,3,2-oxathiaphospholanyl)-N-(tert-butoxycarbonyl)serine methyl ester
475107-22-3

O-(2-thiono-1,3,2-oxathiaphospholanyl)-N-(tert-butoxycarbonyl)serine methyl ester

2-tert-butoxycarbonylamino-3-[(2-cyano-ethoxy)-mercapto-phosphoryloxy]-propionic acid methyl ester
475107-34-7

2-tert-butoxycarbonylamino-3-[(2-cyano-ethoxy)-mercapto-phosphoryloxy]-propionic acid methyl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 3h;97%
ethanol
64-17-5

ethanol

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

Ethyl 3-hydroxypropionimidate hydrochloride
20914-88-9

Ethyl 3-hydroxypropionimidate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether at 20℃; for 3h; Pinner Imino Ether Synthesis; Inert atmosphere;97%
dimethyl diazomalonate
6773-29-1

dimethyl diazomalonate

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

3-propanonitrile

3-propanonitrile

Conditions
ConditionsYield
dirhodium tetraacetate In chloroform96%
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

N-(2-thiono-1,3,2-oxathiaphospholanyl)valine methyl ester

N-(2-thiono-1,3,2-oxathiaphospholanyl)valine methyl ester

2-[(2-cyano-ethoxy)-mercapto-phosphorylamino]-3-methyl-butyric acid methyl ester

2-[(2-cyano-ethoxy)-mercapto-phosphorylamino]-3-methyl-butyric acid methyl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 3h;96%

109-78-4Relevant articles and documents

Liquid-Phase Hydration of Acrylonitrile to Acetamide over the Copper-Nickel Alloy Catalysts

Sugiyama, Kazuo,Miura, Hiroshi,Watanabe, Yoshichika,Ukai, Yasunori

, p. 1579 - 1584 (1987)

The liquid-phase hydration of acrylonitrile to acrylamide has been examined over various metal catalysts at 75 deg C.Five metal elements - Cu, Ag, Fe, Co, and Ni - showed the catalytic conversion of acrylonitrile.The Cu and Ag catalysts gave the acrylamide with a 100 percent selectivity, while the other metals, Fe, Co, and Ni, yielded three products: acrylamide, ehylene cyanohydrin, and bis(2-cyanoethyl) ether.The alloying of Cu and Ni led to an increse in the formation of acrylamide with keeping the high selectivity to acrylamide.Especially, Cu-Ni alloys, with a range of 20-70 percent Cu in their bulk composition, were much more active catalysts than Cu.The maximum yield of acrylamide was obtained on the Cu-Ni alloy catalysts was observed, although such a retardation occurred on the Cu catalyst surface.The maximum synergistic effect was observed over the alloy with the surface component ratio of Cu to Ni of 4; this effect was discussed.

SELECTIVE HYDRATION OF ACRYLONITRILE ON METAL OXIDE CATALYSTS

Miura, Hiroshi,Sugiyama, Kazuo,Kawakami, Soichiro,Aoyama, Toshiyuki,Matsuda, Tsuneo

, p. 183 - 186 (1982)

The selective hydration of acrylonitrile to form acrylamide has been studied on several metal oxide catalysts.MnO2, CuO and Co3O4 catalysts were found to be active and selective.Catalytic activities were strongly affected by the method of preparation.Hydration activity of MnO2 was related to the amount of phenol adsorption.

Preparation method of 3-aminopropanol

-

Paragraph 0064; 0065, (2020/05/05)

The invention relates to a preparation method of 3-aminopropanol, wherein the preparation method comprises the following steps: (1) carrying out a reaction on acrylonitrile with benzyl alcohol under the catalysis of a base catalyst, and separating the obtained reaction solution to obtain 3-benzyloxypropionitrile; and (2) in a liquid-phase reaction system in the presence of a hydrogenation catalyst, carrying out a hydrogenation reaction on the 3-benzyloxypropionitrile, separating the obtained reaction liquid to obtain 3-aminopropanol, and recycling the obtained by-product toluene as an extractant in the step (1).

Method for catalytically synthesizing 3-hydroxylpropionitrile from hydrocyanic acid and epoxyethane

-

Paragraph 0030; 0031; 0032; 0033; 0034; 0035; 0036-0048, (2017/07/20)

The invention relates to a method for catalytically synthesizing 3-hydroxylpropionitrile from hydrocyanic acid and epoxyethane. An activated alumina immobilized boron trifluoride and 1,2-pentanediol complex is used for catalyzing a reaction between hydrocyanic acid and epoxyethane so as to synthesize 3-hydroxylpropionitrile. By the method, during the reaction, a reaction mixture is not required to be neutralized with a large volume of acid, and the generation of a large amount of inorganic salts is absent, so that the reaction has the atom economy of 100%; the reaction route is short, the number of operating steps is small, and the product separation is easy, so that the reaction is simple and convenient in operation; and hydrocyanic acid in a system is free of risk of numerous overflowing under the condition of low-temperature reaction, so that the reaction is safe in operation.

Bio-based nitriles from the heterogeneously catalyzed oxidative decarboxylation of amino acids

Claes, Laurens,Matthessen, Roman,Rombouts, Ine,Stassen, Ivo,De Baerdemaeker, Trees,Depla, Diederik,Delcour, Jan A.,Lagrain, Bert,De Vos, Dirk E.

, p. 345 - 352 (2015/01/30)

The oxidative decarboxylation of amino acids to nitriles was achieved in aqueous solution by in situ halide oxidation using catalytic amounts of tungstate exchanged on a [Ni,Al] layered double hydroxide (LDH), NH4Br, and H2O2 as the terminal oxidant. Both halide oxidation and oxidative decarboxylation were facilitated by proximity effects between the reactants and the LDH catalyst. A wide range of amino acids was converted with high yields, often > 90%. The nitrile selectivity was excellent, and the system is compatible with amide, alcohol, and in particular carboxylic acid, amine, and guanidine functional groups after appropriate neutralization. This heterogeneous catalytic system was applied successfully to convert a pro-tein-rich byproduct from the starch industry into useful biobased N-containing chemicals.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 109-78-4