109-97-7 Usage
Chemical Description
Pyrrole is a chemical moiety that is present in both hit compounds and appears to play a role in controlling selectivity.
Heterocyclic compound
Pyrrole is a five-membered heterocyclic compound which contains one nitrogen atom, it is colorless liquid at room temperature, naturally presents in coal tar and bone oil, turns black color quickly in the air, it has significant irritant odor. The relative density is 0.9691, the boiling point is 130~131℃, freezing point is-24℃. It is almost insoluble in water and dilute alkali solution, soluble in alcohol, ether, benzene and mineral acid solution. It is very stable for alkali, it easily polymerizes into dark red resin trimer in the presence of small amount of inorganic acid, when it is stored, it exposes to light or air will cause resinification. Pyrrole vapor meets loose pieces which moistened with hydrochloric acid can show red, this is called loose piece reaction (pine flakes reaction; pine splint test), it can be used to identify pyrrole. 5 atoms on the pyrrole ring are sp2 hybrid, they are in the same plane, one pair not shared electrons of the nitrogen atom occupy the p-orbital, four carbon atoms and p-orbital are parallel and overlapping, forming 5 atoms, 6 π electrons closed conjugated system, it has aromatic character, prone to electrophilic substitution reactions. Thus, alkalinity of nitrogen atom in pyrrole is small (pKb13.6); On the contrary, combination of hydrogen on the nitrogen atom is weak acid. In addition, pyrrole ring with benzene and other aromatic compounds are same, it can conduct nitration, sulfonation, diazo coupling reaction, Friedel-Crafts type acylation. This reaction can get 2-substituted compound.
Nitrogen atom of pyrrole molecule is sp2 hybridized, unshared electron pair occupys p-orbitals, p-orbitals with parallel 4 sp2 hybridized carbon atoms overlap to form a six-electron conjugated system, it has aromatic character, electrophilic substitution reactions can occur.
Unshared electron pairs of pyrrole nitrogen atoms involve in the conjugated ring system, and binding capacity with H + is very weak, it is not showing alkaline. Since the electron density on the nitrogen atom is relatively lower, the hydrogen atom attached to the nitrogen atom can leave in the form of positive ions, thus pyrrole has faintly acid. Ionization constant Ka = 10-15, it can react with solid potassium hydroxide to form a salt.
Many pyrrole derivatives are important drugs and have strong physiologically active substances, such as chlorophyll, heme.
Pyrrole is basic structural unit of heme, chlorophyll, bile pigments, some amino acids, several alkaloids and some enzymes, these compounds have strong physiological activity and drugs functional. Vitamin B12, glycopyrrolate, kainic acid (drive roundworm medicine), clindamycin (antibiotic) drugs contain hydrogenated pyrrole ring structure. Since 1979, it found that flexible conductive polymer film can be obtained by electrochemical oxidation of pyrrole, the conductivity is 104S/m, and it had good stability.
Chemical Properties
Different sources of media describe the Chemical Properties of 109-97-7 differently. You can refer to the following data:
1. It is colorless to yellowish liquid, long-term storage in the process is easy to expose the action of light and the polymerize to turn brown. It has warm sweet fruity of nuts and esters. Boiling point is 130 ℃ (decomposition), a flash point is 39 ℃, a melting point is-24 ℃. It is soluble in alcohol, ether, benzene, acid and most of the non-volatile oil, insoluble in water and dilute alkali.
2. colourless to brown liquid with chloroform odour
3. Six π-electrons are distributed over the five ring atoms of pyrrole. Delocalization
of these electrons stabilizes the ring and the lone pair of electrons on the nitrogen
atom, which is responsible for the usual basicity of nitrogen compounds, is
involved in the electron cloud, and is not available for sharing. Hence, pyrrole is an extremely weak base and the pyrrolic nitrogen is not readily susceptible to
electrophilic enzymic attack (Damani, 1985). There is a high electron density,
however, at all positions of the ring, which causes pyrrole to be reactive toward
electrophilic substitution. In general, electrophilic substitution reactions on the
neutral molecule occur preferentially at the C-2 or C-5 positions (Jones and Bean,
1977; Damani and Crooks, 1982).
4. Pyrrole has a sweet, warm-ethereal odor reminiscent of chloroform
Uses
Different sources of media describe the Uses of 109-97-7 differently. You can refer to the following data:
1. (1) Spices. The main type use is the preparation of fruit and spice flavors.
(2) It is used for the synthesis of pharmaceuticals and fine chemicals such as perfume
(3) Its derivatives are widely used in organic synthesis, pharmaceuticals, pesticides, spices, rubber vulcanization accelerator, epoxy curing agents of raw materials
(4) It is used as chromatographic analysis standard material, it is also used in organic synthesis and pharmaceutical industry.
(5) It can be used for the pharmaceutical, perfume and other synthetic intermediates.
(6) It is widely used in the synthesis of pharmaceuticals, pesticides and dyes. In the pharmaceutical industry can be used for synthesis of Barossa Star (Irloxacin), meters pyrrole acid (Piromidic), pyrrole pentanone (Pyrovalerone), pyrrole Cain (Pyrrocaine) and set off disease (TMT) and the like.
(7) It can be used to test gold selenite and silicic acid. Determination of chromate, gold, iodine salt, mercury, selenious acid, silicon and vanadium.
2. Pyrrole plays a major role in synthesis of drugs, spices, agrochemicals, dyes, photographic chemicals and perfumes. It plays an important role in the electropolymerisation of macroporous conducting polymer films. It acts as a catalyst for polymerization process; as a standard substance in chromatographic analysis; as corrosion inhibitors and preservatives and as solvents for resins and terpenes. It is utilized to study the hydrogen-bond mediated coupling of 1,2,3-triazole to pyrrole and in the preparation of 1-(4-Chloro-benzoyl)-pyrrole by reacting with 4-Chloro-benzoyl chloride. In Ciamician-Dennstedt rearrangement, It is used to prepare 3-chloropyridine by reacting with dichlorocarbene.
3. Commercial applications of this compoundare very limited. It is used in organic synthesis.Pyrrole is formed by heating albumin orby pyrolysis of gelatin.
4. Manufacture of pharmaceuticals.
Production methods
1, furan and ammonia is as raw materials, γ-alumina is as catalyst, the gas-phase catalytic reaction can get it.
2, After total heat fractionation of the bones oil and sulfuric acid, it converts into its potassium salt (C4H4NK), it is washed with ether and treated with water and then dried, fractionation can derive.It can be obtained by pyrolysis of galactose ammonium in glycerol or mineral oil from pyrolysis.
Hazards & Safety Information
Category: Flammable liquid
Toxicity grading: Highly toxic
Intraperitoneal acute toxicity-mouse LD50: 98 mg/kg; Oral-rabbit LDL0: 147 mg/kg
Flammability hazard characteristics: it is flammable when in case of fire, heat, oxidants; combustion produces toxic fumes of nitrogen oxides
Storage characteristics: Treasury ventilation low-temperature drying; it should be stored separately with oxidants.
Extinguishing agent: Dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.
Occurrence
The pyrrole ring is the basic unit of the porphyrin system which occurs, for
example, in chlorophyll and in hemoglobin. Other pyrrole-based natural products
include pigments such as bilirubin and biliverdin, which are degradative products
from porphyrins (Sundberg, 1984).
Pyrrole has been found in surface waters and in filtrates from cultures of the
blue-green algae, Anabaenaflos aquae. The presence of pyrrole and other organic
nitrogen compounds in natural waters is of environmental concern because they
may exert significant chlorine demand. Pyrrole is also a precursor to trihalomethane
formation (Ram and Morris, 1980).
At ambient temperature, pyrrole can be volatilized from shale oil wastewaters.
Concentrations of approximately 3 g/m3 have been measured indoors in air at an
oil shale wastewater facility (Hawthorne and Sievers, 1984). Pyrrole has been
identified in tobacco smoke, although not in tobacco itself (Johnstone and Plim-mer, 1959); in cigarette smoke (Schumacher et al 1977); in cigar butt aroma (Peck
et al 1969); and in Cannabis smoke condensate (Jones and Foote, 1975).
Pyrrole was found to be naturally occurring in foods; in fact, it is on the Food
and Drug Administration GRAS (Generally Recognized As Safe) list, with an
average usage level of 3 p.p.m. in flavoring formulations (Maga, 1981). Pyrrole is
a volatile constituent of roasted coffee (Gianturco et al 1966), roasted peanuts
(Walradt et al 1971), and fried chicken (Tang et al 1983). It has also been
identified in beef aroma (MacLeod and Coppock, 1976) and is a constituent of
cocoa aroma (Marion et al 1967). It should be noted that all the foods listed have
undergone some degree of thermal treatment; pyrrole was not present in the fresh,
raw foods. In model system studies, pyrrole was among the resulting compounds
when hydroxyproline and glucose were heated under nitrogen at temperatures
ranging from 120° to 200°C. Large amounts of pyrrole were found, as well, when
casein and collagen were pyrolyzed and when proline underwent high temperature
pyrolysis (Maga, 1981).
Definition
Different sources of media describe the Definition of 109-97-7 differently. You can refer to the following data:
1. ChEBI: A tautomer of pyrrole that has the double bonds at positions 2 and 4.
2. pyrrole: An organic nitrogencontainingcompound that formspart of the structure of porphyrins.
Production Methods
Different sources of media describe the Production Methods of 109-97-7 differently. You can refer to the following data:
1. Pyrrole originally was prepared industrially by fractional distillation of coal tar,
bone oil or other protein material, and purified through formation of its potassium
derivative (Runge, 1834; Michelman, 1925). Later it was produced by heating
ammonium mucate with glycerol or mineral oil (Blicke and Powers, 1927;
McElvain and Bollinger, 1941). It is now manufactured by addition of ammonia to
either acetylene or butadiene. Good yields of pyrrole also may be obtained from
the reaction of ammonia with the corresponding heterocyclic compound (furan) in
a vapor-phase process at 480° to 500°C, using alumina as a catalyst (Thompson,
1972) or by catalytic reaction of furan with ammonia over a molybdenum or
vanadium oxide catalyst at 350-400°C (Bishop and Denton, 1950).
2. Pyrrole may be made (1) by reaction of succinimide with zinc and acetic acid, or with hydrogen in the presence of finely divided platinum heated, (2) by reaction of ammonium saccharate or mucate COONH4·(CHOH)4·COONH4 with glycerol at 200 °C by loss of carbon dioxide, ammonia, and water. When pyrrole is treated with potassium (but not with sodium) or boiled with solid potassium hydroxide, potassium pyrrole C4H4NK is formed, which is the starting point for N-derivatives of pyrrole, since reaction of the potassium with halogen of organic compound and with carbon dioxide, readily occurs.
Preparation
By fractional distillation of bone oil (bone oil is obtained by destructive distillation of animal bone) and subsequent purification via the corresponding potassium salt; by thermal decomposition of ammonium mucate in glycerol or mineral oil.
Aroma threshold values
Detection: 20 to 49.6 ppm
General Description
Pyrrole is one of the flavor compounds that is formed in thermally processed foods due to the Maillard reaction.
Health Hazard
Different sources of media describe the Health Hazard of 109-97-7 differently. You can refer to the following data:
1. The toxicity data on pyrrole are scant. Itis moderately toxic on test animals. Theroutes of exposure are inhalation of vapors,ingestion, and skin absorption. Vapors arean irritant to the eyes and respiratory tract.The lethal doses in rabbits by oral anddermal routes are within the range 150 and250 mg/kg, respectively.
2. Pyrrole is harmful if swallowed, inhaled, or absorbed through the skin. Its vapor or
mist is irritating to the eyes, mucous membranes and upper respiratory tract
(Lenga, 1985; Sax, 1984). Although no cases of occupational disease due to
pyrrole have been reported, it has a depressant action on the central nervous
system and, in severe intoxication, it is injurious to the liver. Tests indicate that it
has moderate cumulative toxicity (Parmegianni, 1983).
Fire Hazard
Combustible liquid; flash point (closed cup)
39°C (102°F); vapor forms explosive mixtures
with air; LEL and UEL values are not
available. Heating with strong oxidizers can
be violent.
Industrial uses
Different sources of media describe the Industrial uses of 109-97-7 differently. You can refer to the following data:
1. Pyrrole is a five-member nitrogen heterocyclic ring that contains two carbon-carbon
double bond configurations which gives the solvent a pronounced aromatic
character. Pyrrole is an intermediate in the synthesis of a variety of commercial
chemical derivatives. Pyrrole has only limited solubility
in water but are miscible with many organic solvents.Pyrrole when freshly distilled
is a colorless liquid, but the solvent can rapidly acquire a brown coloration due to
air oxidation. Prolonged standing in the air will promote slow polymerization of the
pyrrole to give a dark brown polymer. Pyrrole has a viscosity of 1.31 centipoise
and a medium surface tension value of 37.1 dynes/cm.pyrrole is used as a chemical intermediate in the
preparation of electrically conducting polypyrrole by means of an electrochemical
polymerization process. Pyrrole has few other industrial uses.
2. Pyrrole is used to a limited extent as a solvent for polymeric esters, but its primary
value lies in its function as a chemical intermediate. It is used in the synthesis of
non-heterocyclic compounds (Kozikowski, 1984) and its derivatives have been
used in the manufacture of dyes, herbicides, perfumes, and as cross-linking agents
for curing resins (Thompson, 1972). Derivatives of pyrrole are utilized in pharmaceutical
applications, particularly as anti-inflammation drugs and drugs with
central nervous system activity, including antihypertensive effects (Sundberg,
1984); and as antimicrobial agents (Freeman, 1975), such as fungicides (Zirngibl,
1983) and bactericides (Bailey and Johnson, 1973; Bailey et al 1973; Sundberg,
1984). Polymers of pyrrole have been used in the preparation of photoconductive
materials. The main utility of poly(pyrrole) has been for the modification of
electrode surfaces, although numerous other applications can be envisioned (Heilmann
and Rasmussen, 1984).
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. Flammable liquid when exposed to heat or flame; can react with oxilzing materials. To fight fire, use foam, CO2, dry chemical. Violent reaction with 2-nitrobenzaldehyde.
When heated to decomposition it emits highly toxic fumes of NOx.
Metabolism
Reports concerning the metabolites formed following administration of pyrrole
have been somewhat confusing. Saccardi (1919a, 1920) observed that administration
of pyrrole orally and by injection resulted in the formation of melanin in the
urine of rabbits, but not of dogs. Unchanged pyrrole was also found in the urine of
rabbits after injection of pyrrole (Saccardi, 1919b). Shimizu (1921) isolated
methylpyridine from the urine of rabbits and dogs given pyrrole and suggested that
pyrrole could be converted to pyridine derivatives in vivo. The transformations in
the body and the excretion products in the urine are, however, in question
(Fairhall, 1969). Novello (1927) injected rabbits subcutaneously with 0.5 g doses
of pyrrole hydrochloride and attempted to detect acetyl or methyl derivatives, but
was unsucessful. Approximately 40-50% of the nitrogen of the injected pyrrole
was excreted as urea. By the process of elimination, Novello (1927) concluded that the nitrogen not accounted for as urea nitrogen was excreted as unchanged
pyrrole. It did not appear that the pyrrole was oxidized to a secondary or tertiary
alcohol because there was no rise in ethereal sulfate or conjugated glucuronic acid
excretion. Kusui (1935) injected frogs with pyrrole and noted that although the
urine smelled of pyrrole, no free base could be isolated. Damani and Crooks
(1982) have suggested that pyrrole may be a likely substrate for hydroxylation at
C-2 and C-5, leading to ring opened products. They have not, however, studied the
biotransformation of pyrrole, but based their hypothesis on studies of the metabolism
of indole.
Pyrrole may affect the biotransformation of other compounds. Bernheim et al
(1938) observed that pyrrole acted as a catalyst for the oxidation of amines and
certain non-natural amino acids and catalyzed the formation of methemoglobin
from hemoglobin. On the other hand, pretreatment of rats with 100 mg/kg pyrrole
inhibited markedly the metabolism of dimethylnitrosamine in terms of both C02
excretion and decline in blood dimethylnitrosamine concentration (Phillips et al
1982).
Purification Methods
Dry pyrrole with NaOH, CaH2 or CaSO4. Fractionally distil it under reduced pressure from CaH2. Store it under nitrogen as it turns brown in air. Redistil it immediately before use. The picrate forms orange-red crystals with m 69o(dec). [Beilstein 20 H 4, 20 I 3, 20 II 3, 20 III/IV 61, 20/5 V 3.]
Check Digit Verification of cas no
The CAS Registry Mumber 109-97-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 109-97:
(5*1)+(4*0)+(3*9)+(2*9)+(1*7)=57
57 % 10 = 7
So 109-97-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H5N/c1-2-4-5-3-1/h1-5H
109-97-7Relevant articles and documents
1-pyrrole from Trimethyl(1-pyrrolyl)ammonium Ion
Zeltner, Peter,Bernauer, Karl
, p. 1860 - 1864 (1983)
Trimethyl(1-pyrrolyl)ammonium iodide (5a) and the corresponding p-toluenesulfonate 5b are transformed by strong bases into 1-pyrrole (9), i.e. into a N-Mannich base, a type of compound novel in the pyrrole series.In this reaction, which is very fast in DMSO the cation of compounds 5 is deprotonated to form the nitrogen ylide 6.The latter undergoes a Stevens-type rearrangement to 9.Several facts, namely the negative outcome of a cross-reaction experiment with 3,4-dimethylpyrrole and of an attempt to obtain 9 from pyrrole and dimethyl(methylidene)ammonium iodide in the presence of one equivalent of sodium methoxide, as well as unsuccessful CIDNP studies point to a rearrangement mechanism via the contact ion pair 12.
Devinylation of N-vinylpyrroles using mercury(II) acetate
Schmidt,Vasil'Tsov,Zorina,Ivanov,Mikhaleva,Trofimov
, p. 1300 - 1303 (2012)
-
-
Haitinger
, p. 228 (1882)
-
-
Tsukamoto,Lichtin
, p. 3798 (1960)
-
-
Whitten et al.
, p. 322 (1966)
-
Flash flow pyrolysis: Mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment
Cantillo, David,Sheibani, Hassan,Kappe, C. Oliver
, p. 2463 - 2473 (2012)
Flash vacuum pyrolysis (FVP) is a gas-phase continuous-flow technique where a substrate is sublimed through a hot quartz tube under high vacuum at temperatures of 400-1100 °C. Thermal activation occurs mainly by molecule-wall collisions with contact times in the region of milliseconds. As a preparative method, FVP is used mainly to induce intramolecular high-temperature transformations leading to products that cannot easily be obtained by other methods. It is demonstrated herein that liquid-phase high-temperature/high- pressure (high-T/p) microreactor conditions (160-350 °C, 90-180 bar) employing near- or supercritical fluids as reaction media can mimic the results obtained using preparative gas-phase FVP protocols. The high-T/p liquid-phase "flash flow pyrolysis" (FFP) technique was applied to the thermolysis of Meldrum's acid derivatives, pyrrole-2,3-diones, and pyrrole-2-carboxylic esters, producing the expected target heterocycles in high yields with residence times between 10 s and 10 min. The exact control over flow rate (and thus residence time) using the liquid-phase FFP method allows a tuning of reaction selectivities not easily achievable using FVP. Since the solution-phase FFP method does not require the substrate to be volatile any more -a major limitation in classical FVP-the transformations become readily scalable, allowing higher productivities and space-time yields compared with gas-phase protocols. Differential scanning calorimetry measurements and extensive DFT calculations provided essential information on pyrolysis energy barriers and the involved reaction mechanisms. A correlation between computed activation energies and experimental gas-phase FVP (molecule-wall collisions) and liquid-phase FFP (molecule-molecule collisions) pyrolysis temperatures was derived.
Chlorination of Pyrrole. N-Chloropyrrole: Formation and Rearrangement to 2- and 3-Chloropyrrole
Rosa, Michael De
, p. 1008 - 1010 (1982)
N-Chloropyrrole (2) was formed in 65-72percent yield when pyrrole (1) in CCl4 was chlorinated with aqueous NaOCl.This intermediate rearranged in methanol to give chloropyrroles by two distinct reactions: a thermal rearrangement which gave 2-chloropyrrole (3) and an acid-catalyzed intermolecular reaction which gave 2-chloropyrrole (3), 3-chloropyrrole (4), and 2,5-dichloropyrrole (5).Nucleophilic attack on the N-Cl bond of 2 was demonstrated by reactions in the presence of CN- and SCN-.In the latter case, 2-(thiocyano)pyrrole was formed.
Kinetics of elimination of several heterocyclic carbamates in the gas phase
Brusco, Yannely,Dominguez, Rosa M.,Rotinov, Alexandra,Herize, Armando,Cordova, Mary,Chuchani, Gabriel
, p. 796 - 800 (2002)
The kinetics of the gas-phase elimination of several heterocyctic carbamates were determined in a static system over the temperature range 190.0-409.7°C and the pressure range 26.5-125 Torr (1 Torr = 133.3 Pa). The reactions in seasoned vessels, with the free radical inhibitor cyciohexene and/or toluene always present, are homogeneous and unimolecular and obey a first-order rate law. The observed rate coefficients are represented by the following Arrhenius equations: for tert-butyl-1-pyrrolidine carboxylate, log k1 (s-1) = (11.36 ± 0.31) - (145.4 ± 3.1) kJ mol-1 (2.303RT)-1; for 1-(tert-butoxycarbonyl)-2-pyrrolidinone, log k1 (s-1) = (11.54 ± 0.29) - (140.8 ± 2.8) kJ mol-1 (2.303RT)-1; for tert-butyl-1-pyrrole carboxylate, log k1 (s-1): (12.12 ± 0.05) - (145.2 ± 1.0) kJ mol-1 (2.303RT)-1; and for 1-ethylpiperazine carboxylate, log k1 (s-1): (12.05 ± 0.19) - (188.2 ± 4.6) kJ mol-1 (2.303RT)-1 The saturated heterocyclic carbamates show a decrease in rates of elimination due to electronic factors. Heterocyclic carbamates with a nitrogen atom able to delocalize its electrons with π-bonds present in the ring were found to enhance the rates due to resonance interactions. Copyright
Decarboxylation via addition of water to a carboxyl group: Acid catalysis of pyrrole-2-carboxylic acid
Mundle, Scott O. C.,Kluger, Ronald
, p. 11674 - 11675 (2009)
(Chemical Equation Presented) The decarboxylation of pyrrole-2-carboxylic acid is subject to acid catalysis in strongly acidic solutions. Protonation of the pyrrole ring at C2 produces a potentially low-energy carbanion leaving group. Carbon dioxide forma
Sulfoxylate Anion Radical-Induced Aryl Radical Generation and Intramolecular Arylation for the Synthesis of Biarylsultams
Gupta, Pankaj,Laha, Joydev K.
supporting information, (2022/03/16)
Aryl radical generation from the corresponding aryl halides using an electron donor and subsequent intramolecular cyclization with arenes could be an important advancement in contemporary biaryl synthesis. A green and practically useful synthetic protocol to access diverse six- and seven-membered biarylsultams especially with a free NH group including demonstration of a gram-scale synthesis is reported herein. The sulfoxylate anion radical (SO2-?), generated in situ from the reagents rongalite or sodium dithionite (Na2S2O4), was found to be the key single electron transfer agent forming aryl radicals from aryl halides, which upon intramolecular arylation gives biarylsultams with good to excellent yields. The approach features generation of aryl radicals that remained underexplored, use of a cheap and readily available industrial reagents, and transition metal-free, mild, and green reaction conditions.
Rearrangement and cyclisation reactions on the 1-Arylpyrrol-2-iminyl-2-Aryliminopyrrol-1-yl radical energy surface
Borthwick, Scott,Foot, Jonathan,Ieva, Maria,McNab, Hamish,McNab, Lilian,Rozgowska, Emma J.,Wright, Andrew
supporting information, p. 161 - 175 (2021/02/02)
Independent generation of the iminyl (X = N) and pyrrol-1-yl (X = N) radicals by flash vacuum pyrolysis of the corresponding oxime ether and N-(dimethylamino) compound, respectively, provides two regioisomeric pyrrolo1,2-A]quinoxalines compounds. This shows that the radical species interconvert via the spirodienyl moeity at high temperatures. Corresponding generation of the pyrrol-1-yl (X = CH) radical gives the pyrrolo[1,2-A]quinoline as the only cyclised product. In this case, DFT calculations suggest that direct cyclisation of the pyrrol-1-yl takes place, rather than formation of the spirodienyl species and exclusive migration of the C-N bond.
