109053-82-9

Basic information

• Product Name: (R)-methyl 3-(dimethyl(phenyl)silyl)pentanoate
• Synonyms: (R)-methyl 3-(dimethyl(phenyl)silyl)pentanoate
• CAS NO: 109053-82-9
• Molecular Weight: 250.413
• Mol File: 109053-82-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-methyl 3-(dimethyl(phenyl)silyl)pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 3-(dimethyl(phenyl)silyl)pentanoate(109053-82-9)
• EPA Substance Registry System: (R)-methyl 3-(dimethyl(phenyl)silyl)pentanoate(109053-82-9)

Safety Data

• Hazardous Substances Data: 109053-82-9(Hazardous Substances Data)

Upstream product

• 768-33-2 phenyldimethylsilyl chloride 
• 185990-03-8 dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane 
• 925-90-6 ethylmagnesium bromide 
• 88761-82-4 methyl β-(E)-2-dimethylphenylsilylacrylate 
• 109053-88-5 (E)-3-[dimethyl(phenyl)silyl]propenoic acid 

Downstream Products

• 42558-50-9 methyl (3R)-3-hydroxypentanoate 

Relevant articles and documents

Asymmetric Conjugate Addition of Grignard Reagents to 3-Silyl Unsaturated Esters for the Facile Preparation of Enantioenriched β-Silylcarbonyl Compounds and Allylic Silanes

A highly enantioselective conjugate addition of Grignard reagents to 3-silyl unsaturated esters to deliver synthetically useful chiral β-silylcarbonyl compounds was developed. The synthetic value of this methodology was further illustrated by the synthesis of enantioenriched β-hydroxyl esters and the facile access granted to various α-chiral allylic silanes. A plethora of diastereoselective transformations of β-silylenolates were also investigated and afforded manifold organosilanes that contained contiguous stereogenic centers with excellent enantioselectivity.