109162-32-5Relevant articles and documents
Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy
Li, Yujie,Peng, Peng,Tang, Li,Hu, Yunzhen,Hu, Yongzhou,Sheng, Rong
, p. 4717 - 4725 (2014)
A series of novel 2-methoxy-phenyl dimethyl-carbamate derivatives were designed, synthesized and evaluated as site-activated MTDLs based on rivastigmine and curcumin. Most of them exhibited good to excellent AChE and BuChE inhibitory activities with sub-m
Synthesis and biological evaluation of a new class of multi-target heterocycle piperazine derivatives as potential antipsychotics
Gao, Lanchang,Hao, Chao,Ma, Ru,Chen, Jiali,Zhang, Guisen,Chen, Yin
, p. 16931 - 16941 (2021/05/25)
In this study, we designed and synthesized a novel series of multi-receptor ligands as polypharmacological antipsychotic agents by using a multi-receptor affinity strategy. Among them,3wcombines a multi-receptor mechanism with high mixed affinities for D
Compounds and methods for treatment of amyloid-B-peptide related disorders
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Page/Page column 21, (2008/06/13)
The present invention relates to compounds, preparation and uses thereof, particularly in the pharmaceutical industry. The present invention discloses novel compounds of the following formula (I) more particularly useful for the treatment of Alzheimer's d