1094070-46-8Relevant articles and documents
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity
Voss, Matthew E.,Rainka, Matthew P.,Fleming, Mike,Peterson, Lisa H.,Belanger, David B.,Siddiqui, M. Arshad,Hruza, Alan,Voigt, Johannes,Gray, Kimberly,Basso, Andrea D.
scheme or table, p. 3544 - 3549 (2012/06/18)
The structure-activity relationships of new Aurora A/B kinase inhibitors derived from the previously identified kinase inhibitor 12 are described. Introduction of acetic acid amides onto the pyrazole of compound 12 was postulated to influence Aurora A/B selectivity and improve the profile against off-target kinases. The SAR of the acetic acid amides was explored and the effect of substitution on enzyme inhibition as well as mechanism-based cell activity was studied. Additionally, several of the more potent inhibitors were screened for their off-target kinase selectivity.
IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS
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Page/Page column 40; 41, (2009/09/05)
In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or Aurora kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, metho