109614-27-9

Basic information

• Product Name: 4-(4-methoxy-trans-styryl)-7-methyl-coumarin
• CAS NO: 109614-27-9
• Molecular Weight: 292.334
• Mol File: 109614-27-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-methoxy-trans-styryl)-7-methyl-coumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxy-trans-styryl)-7-methyl-coumarin(109614-27-9)
• EPA Substance Registry System: 4-(4-methoxy-trans-styryl)-7-methyl-coumarin(109614-27-9)

Safety Data

• Hazardous Substances Data: 109614-27-9(Hazardous Substances Data)

Upstream product

• 14002-90-5 4,7-dimethyl-coumarin 
• 123-11-5 4-methoxy-benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 50402-83-0 7-methylcoumarin-4-acetic acid 
• 142009-38-9 4-(4-hydroxy-trans-styryl)-7-methyl-coumarin 
• 77-78-1 dimethyl sulfate 
• 110-89-4 piperidine 

Downstream Products

• 134778-76-0 2,11-Bis-(4-methoxy-phenyl)-7-methyl-3a,3b,11,11a-tetrahydro-chromeno[3,4-e]isoindole-1,3,4-trione 
• 134778-74-8 2-Benzyl-11-(4-methoxy-phenyl)-7-methyl-3a,3b,11,11a-tetrahydro-chromeno[3,4-e]isoindole-1,3,4-trione 
• 134778-72-6 11-(4-Methoxy-phenyl)-2,7-dimethyl-3a,3b,11,11a-tetrahydro-chromeno[3,4-e]isoindole-1,3,4-trione 
• 134778-69-1 4-(2-hydroxy-4-methyl-phenyl)-6-(4-methoxy-phenyl)-cyclohex-4-ene-1,2,3-tricarboxylic acid-1,2-anhydride-3-lactone 
• 123936-69-6 4-(4-methoxy-β-o-tolylmercapto-phenethyl)-7-methyl-coumarin 
• 115096-93-0 4-(4-methoxy-β-phenylsulfanyl-phenethyl)-7-methyl-coumarin 

Relevant articles and documents

Design, synthesis, and molecular modeling of coumarin derivatives as MDM2 inhibitors targeting breast cancer

The coumarin ring was used as a central scaffold that was substituted with a variety of bioactive functional groups, for designing and synthesizing novel MDM2 inhibitors targeting breast cancer. The synthesized derivatives, 3c, 3d, 3g, 7b, 7c and 8 with IC50s ranging from 9.4 to 9.9?μM were evaluated for their safety on MCF10a normal breast cell line. The compounds showed selectivity indices of 2.15, 3.85, 2.75, 1.38, 3.72 and 5.20 respectively. 7c was selected for further investigation, the compound was capable of down-regulating MDM2 and the anti-apoptosis proteins Bcl-2 and Bcl-xL, up-regulating the level of p53 and the pro-apoptosis protein BAX, causing cell cycle arrest at G2/M phase and activating Caspase-9 to induce apoptosis. Molecular docking study revealed the capability of derivative 7c to interact with the key amino acids in p53 binding pocket of MDM2 protein. Moreover, the physicochemical properties of compound 7c were studied in silico.