1097777-74-6Relevant articles and documents
FXR agonist activity of conformationally constrained analogs of GW 4064
Akwabi-Ameyaw, Adwoa,Bass, Jonathan Y.,Caldwell, Richard D.,Caravella, Justin A.,Chen, Lihong,Creech, Katrina L.,Deaton, David N.,Madauss, Kevin P.,Marr, Harry B.,McFadyen, Robert B.,Miller, Aaron B.,Navas III, Frank,Parks, Derek J.,Spearing, Paul K.,Todd, Dan,Williams, Shawn P.,Bruce Wisely
supporting information; experimental part, p. 4733 - 4739 (2010/06/12)
Two series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either benzothiophene or naphthalene rings led to the identification of potent full agonists 2a and 2g.