109806-78-2Relevant articles and documents
A NEW AND CONVENIENT SYNTHESIS OF PROTOBERBERINE ALKALOIDS: (+/-)-TETRAHYDROPALMATINE, (+/-)-SINACTINE, (+/-)-CANADINE AND-)-STYLOPINE
Yasuda, Shingo,Hirasawa, Taeko,Hanaoka, Miyoji
, p. 2399 - 2402 (1987)
2,3,9,10-Tetraoxygenated protoberberine alkaloids (14) were efficiently synthesized from the readily available benzaldehyde (2 or 10) via the benzylphenethylamines (11) and 2-phenethylisoquinolin-3-ones (12 or 13).
Synthesis and antihyperglycemic evaluation of various protoberberine derivatives
Bian, Xiaoli,He, Langchong,Yang, Guangde
, p. 1380 - 1383 (2007/10/03)
Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of β-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.